Acalabrutinib Related Compounds & Impurities

Acalabrutinib is a second-generation, highly selective Bruton's tyrosine kinase (BTK) inhibitor used in chronic lymphocytic leukaemia and mantle cell lymphoma, designed to minimise off-target kinase inhibition.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Acalabrutinib reference standards, pharmacopeial and non-pharmacopeial Acalabrutinib impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Acalabrutinib-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Acalabrutinib
Acalabrutinib
  • CAT. No.A1500000
  • CAS. No.1420477-60-6
  • Mol. F.C26H23N7O2
  • Mol. W.465.51 g/mol
  • Stock Status:Instock
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(5-Chloro pyrazin-2-yl) Methanamine
(5-Chloro pyrazin-2-yl) Methanamine
  • CAT. No.A1500004
  • CAS. No.1060814-53-0
  • Mol. F.C5H6ClN3
  • Mol. W.143.57 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 5
Acalabrutinib Impurity 5
  • CAT. No.A1500005
  • CAS. No.NA
  • Mol. F.C26H25N7O3
  • Mol. W.483.52 g/mol
  • Stock Status:Custom Synthesis
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3,5-Dichloro-2-pyrazinemethanamine
3,5-Dichloro-2-pyrazinemethanamine
  • CAT. No.A1500006
  • CAS. No.1211531-66-6
  • Mol. F.C5H5Cl2N3
  • Mol. W.178.00 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 7
Acalabrutinib Impurity 7
  • CAT. No.A1500007
  • CAS. No.2180911-32-2
  • Mol. F.C18H21BN2O3
  • Mol. W.324.20 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 8
Acalabrutinib Impurity 8
  • CAT. No.A1500008
  • CAS. No.2180911-29-7
  • Mol. F.C18H21BN2O3
  • Mol. W.324.20 g/mol
  • Stock Status:Custom Synthesis
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B-[2-[(2-Pyridinylamino)carbonyl]phenyl]boronic Acid
B-[2-[(2-Pyridinylamino)carbonyl]phenyl]boronic Acid
  • CAT. No.A1500010
  • CAS. No.2096331-92-7
  • Mol. F.C12H11BN2O3
  • Mol. W.242.04 g/mol
  • Stock Status:Custom Synthesis
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(3-(pyridin-2-ylcarbamoyl)phenyl)boronic acid
(3-(pyridin-2-ylcarbamoyl)phenyl)boronic acid
  • CAT. No.A1500011
  • CAS. No.874459-98-0
  • Mol. F.C12H11BN2O3
  • Mol. W.242.04 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 11
Acalabrutinib Impurity 11
  • CAT. No.A1500012
  • CAS. No.2490433-97-9
  • Mol. F.C30H25N7O3
  • Mol. W.531.56 g/mol
  • Stock Status:Instock
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Acalabrutinib -N-Oxide
Acalabrutinib -N-Oxide
  • CAT. No.A1500013
  • CAS. No.NA
  • Mol. F.C26H23N7O3
  • Mol. W.481.51 g/mol
  • Stock Status:Custom Synthesis
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(R)-2-(4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)benzamido)pyridine 1-oxide
(R)-2-(4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)benzamido)pyridine 1-oxide
  • CAT. No.A1500014
  • CAS. No.NA
  • Mol. F.C26H23N7O3
  • Mol. W.481.51 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Acetaldehyde
Acalabrutinib Acetaldehyde
  • CAT. No.A1500015
  • CAS. No.NA
  • Mol. F.C26H25N7O3
  • Mol. W.483.52 g/mol
  • Stock Status:Instock
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Acalabrutinib 8-Hydroxy Impurity
Acalabrutinib 8-Hydroxy Impurity
  • CAT. No.A1500016
  • CAS. No.NA
  • Mol. F.C26H22N6O3
  • Mol. W.466.49 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Nitroso Impurity 1
Acalabrutinib Nitroso Impurity 1
  • CAT. No.A1500018
  • CAS. No.NA
  • Mol. F.C22H20N8O2
  • Mol. W.428.45 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 25
Acalabrutinib Impurity 25
  • CAT. No.A1500019
  • CAS. No.1420478-90-5
  • Mol. F.C22H21N7O
  • Mol. W.399.45 g/mol
  • Stock Status:Instock
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Acalabrutinib R-Isomer
Acalabrutinib R-Isomer
  • CAT. No.A1500020
  • CAS. No.1952316-43-6
  • Mol. F.C26H23N7O2
  • Mol. W.465.51 g/mol
  • Stock Status:Instock
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Acalabrutinib impurity 1
Acalabrutinib impurity 1
  • CAT. No.A1500021
  • CAS. No.289677-06-1
  • Mol. F.C18H24N2O4
  • Mol. W.332.39 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 20
Acalabrutinib Impurity 20
  • CAT. No.A1500022
  • CAS. No.1418307-17-1
  • Mol. F.C18H19ClN4O3
  • Mol. W.374.80 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 21
Acalabrutinib Impurity 21
  • CAT. No.A1500023
  • CAS. No.1418307-18-2
  • Mol. F.C18H17ClN4O2
  • Mol. W.356.80 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 22
Acalabrutinib Impurity 22
  • CAT. No.A1500024
  • CAS. No.1420478-87-0
  • Mol. F.C18H16BrClN4O2
  • Mol. W.435.70 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 23 (S-isomer)
Acalabrutinib Impurity 23 (S-isomer)
  • CAT. No.A1500025
  • CAS. No.NA
  • Mol. F.C18H17BrN4O3
  • Mol. W.417.26 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 24
Acalabrutinib Impurity 24
  • CAT. No.A1500026
  • CAS. No.2198380-46-8
  • Mol. F.C18H18BrN5O2
  • Mol. W.416.30 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Nitroso Impurity 2
Acalabrutinib Nitroso Impurity 2
  • CAT. No.A1500027
  • CAS. No.NA
  • Mol. F.C17H16N6O3
  • Mol. W.352.35 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 27
Acalabrutinib Impurity 27
  • CAT. No.A1500028
  • CAS. No.1420478-88-1
  • Mol. F.C18H18BrN5O2
  • Mol. W.416.27 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 30
Acalabrutinib Impurity 30
  • CAT. No.A1500029
  • CAS. No.4589-12-2
  • Mol. F.C12H10N2O
  • Mol. W.198.22 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 31
Acalabrutinib Impurity 31
  • CAT. No.A1500030
  • CAS. No.NA
  • Mol. F.C19H21ClN4O3
  • Mol. W.388.85 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 28
Acalabrutinib Impurity 28
  • CAT. No.A1500031
  • CAS. No.2170801-87-1
  • Mol. F.C18H19N5O2
  • Mol. W.337.38 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 32
Acalabrutinib Impurity 32
  • CAT. No.A1500032
  • CAS. No.1803707-17-6
  • Mol. F.C7H2Br2F2O2
  • Mol. W.315.89 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 23
Acalabrutinib Impurity 23
  • CAT. No.A1500033
  • CAS. No.NA
  • Mol. F.C18H17BrN4O3
  • Mol. W.417.26
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 2
Acalabrutinib Impurity 2
  • CAT. No.A1500034
  • CAS. No.NA
  • Mol. F.C21H19N5O3
  • Mol. W.389.41 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Maleate Monohydrate
Acalabrutinib Maleate Monohydrate
  • CAT. No.A1500035
  • CAS. No.2641500-53-8
  • Mol. F.C26H23N7O2.C4H4O4.H2O
  • Mol. W.599.59 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 36
Acalabrutinib Impurity 36
  • CAT. No.A1500036
  • CAS. No.1420478-89-2
  • Mol. F.C30H27N7O3
  • Mol. W.533.58 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 33
Acalabrutinib Impurity 33
  • CAT. No.A1500037
  • CAS. No.2230757-49-8
  • Mol. F.C22H19N7O
  • Mol. W.397.43 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 17
Acalabrutinib Impurity 17
  • CAT. No.A1500038
  • CAS. No.2412166-56-2
  • Mol. F.C30H25N7O3
  • Mol. W.531.57 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Acetyl Impurity
Acalabrutinib Acetyl Impurity
  • CAT. No.A1500039
  • CAS. No.NA
  • Mol. F.C24H23N7O2
  • Mol. W.441.49 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 34
Acalabrutinib Impurity 34
  • CAT. No.A1500040
  • CAS. No.NA
  • Mol. F.C26H22N6O3
  • Mol. W.466.49 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 9
Acalabrutinib Impurity 9
  • CAT. No.A1500042
  • CAS. No.NA
  • Mol. F.C18H18BrN5O2
  • Mol. W.416.27 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 10
Acalabrutinib Impurity 10
  • CAT. No.A1500043
  • CAS. No.NA
  • Mol. F.C18H18BrN5O2
  • Mol. W.416.27 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 41
Acalabrutinib Impurity 41
  • CAT. No.A1500044
  • CAS. No.NA
  • Mol. F.C18H17Br2N5O2
  • Mol. W.495.17 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 42
Acalabrutinib Impurity 42
  • CAT. No.A1500045
  • CAS. No.NA
  • Mol. F.C18H17Br2N5O2
  • Mol. W.495.17 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 6
Acalabrutinib Impurity 6
  • CAT. No.A1500046
  • CAS. No.NA
  • Mol. F.C10H11BrN6O
  • Mol. W.311.14 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 12
Acalabrutinib Impurity 12
  • CAT. No.A1500047
  • CAS. No.NA
  • Mol. F.C10H9BrClN5O
  • Mol. W.330.57 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 13
Acalabrutinib Impurity 13
  • CAT. No.A1500048
  • CAS. No.NA
  • Mol. F.C10H10ClN5O
  • Mol. W.251.67 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 14
Acalabrutinib Impurity 14
  • CAT. No.A1500051
  • CAS. No.NA
  • Mol. F.C48H44N14O3
  • Mol. W.864.95 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 15
Acalabrutinib Impurity 15
  • CAT. No.A1500052
  • CAS. No.NA
  • Mol. F.C26H23N7O3
  • Mol. W.481.51 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 18
Acalabrutinib Impurity 18
  • CAT. No.A1500053
  • CAS. No.NA
  • Mol. F.C45H42N14O2
  • Mol. W.810.91 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 19
Acalabrutinib Impurity 19
  • CAT. No.A1500054
  • CAS. No.NA
  • Mol. F.C26H24BrN7O2
  • Mol. W.546.42 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 26
Acalabrutinib Impurity 26
  • CAT. No.A1500055
  • CAS. No.NA
  • Mol. F.C52H46N14O4
  • Mol. W.931.01 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 16
Acalabrutinib Impurity 16
  • CAT. No.A1500056
  • CAS. No.NA
  • Mol. F.C52H46N14O4
  • Mol. W.931.01 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Benzyl Impurity
Acalabrutinib Benzyl Impurity
  • CAT. No.A1500057
  • CAS. No.NA
  • Mol. F.C29H27N7O
  • Mol. W.489.57 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 29
Acalabrutinib Impurity 29
  • CAT. No.A1500058
  • CAS. No.NA
  • Mol. F.C26H23N7O3
  • Mol. W.481.51 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib-N-Formyl
Acalabrutinib-N-Formyl
  • CAT. No.A1500059
  • CAS. No.NA
  • Mol. F.C23H21N7O2
  • Mol. W.427.46 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Acalabrutinib Impurity 1
N-Nitroso Acalabrutinib Impurity 1
  • CAT. No.A1500060
  • CAS. No.NA
  • Mol. F.C26H22N8O3
  • Mol. W.494.50 g/mol
  • Stock Status:Custom Synthesis
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Acalabrutinib Impurity 3
Acalabrutinib Impurity 3
  • CAT. No.A1500061
  • CAS. No.NA
  • Mol. F.C43H38N12O3
  • Mol. W.770.80 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

Acalabrutinib Metabolite 27
Acalabrutinib Metabolite 27
  • CAT. No.A1500002
  • CAS. No.2230757-47-6
  • Mol. F.C26H23N7O3
  • Mol. W.481.51 g/mol
  • Stock Status:Instock
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Isotope Labelled Compounds

Acalabrutinib-D4
Acalabrutinib-D4
  • CAT. No.A1500001
  • CAS. No.1420477-60-6 (Unlabeled)
  • Mol. F.C26H19D4N7O2
  • Mol. W.469.54 g/mol
  • Stock Status:Instock
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Acalabrutinib Metabolite-D4
Acalabrutinib Metabolite-D4
  • CAT. No.A1500003
  • CAS. No.2230757-47-6(Unlabeled)
  • Mol. F.C26H19D4N7O3
  • Mol. W.485.53 g/mol
  • Stock Status:Under Synthesis
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Acalabrutinib Metabolite-D4
Acalabrutinib Metabolite-D4
  • CAT. No.A1500017
  • CAS. No.2230757-47-6(Unlabeled)
  • Mol. F.C26H19D4N7O3
  • Mol. W.485.53 g/mol
  • Stock Status:Under Synthesis
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Calquence D4
Calquence D4
  • CAT. No.A1500041
  • CAS. No.NA
  • Mol. F.C26H19D4N7O2
  • Mol. W.469.53 g/mol
  • Stock Status:Instock
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