Agomelatine Related Compounds & Impurities

Agomelatine is a melatonergic MT1/MT2 agonism with 5-HT2C antagonism, regulate circadian-rhythm normalising effects with a favourable tolerability profile.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Agomelatine reference standards, pharmacopeial and non-pharmacopeial Agomelatine impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Agomelatine-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Agomelatine
Agomelatine
  • CAT. No.A440000
  • CAS. No.138112-76-2
  • Mol. F.C15H17NO2
  • Mol. W.243.30 g/mol
  • Stock Status:Instock
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Agomelatine Impurity 10 Hydrobromide
Agomelatine Impurity 10 Hydrobromide
  • CAT. No.A440001
  • CAS. No.144705-51-1
  • Mol. F.C12H14BrNO
  • Mol. W.268.15 g/mol
  • Stock Status:Custom Synthesis
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Agomelatine Dimer Urea
Agomelatine Dimer Urea
  • CAT. No.A440002
  • CAS. No.185421-27-6
  • Mol. F.C27H28N2O3
  • Mol. W.428.52 g/mol
  • Stock Status:Instock
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Agomelatine Impurity 8
Agomelatine Impurity 8
  • CAT. No.A440004
  • CAS. No.152302-45-9
  • Mol. F.C14H15NO2
  • Mol. W.229.27 g/mol
  • Stock Status:Instock
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Agomelatine Impurity 9
Agomelatine Impurity 9
  • CAT. No.A440005
  • CAS. No.166527-00-0
  • Mol. F.C14H15NO3
  • Mol. W.245.27 g/mol
  • Stock Status:Limited Stock
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Agomelatine Impurity 11
Agomelatine Impurity 11
  • CAT. No.A440006
  • CAS. No.166526-99-4
  • Mol. F.C15H17NO3
  • Mol. W.259.30 g/mol
  • Stock Status:Instock
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7-Methoxy-1-naphthaleneethanol
7-Methoxy-1-naphthaleneethanol
  • CAT. No.A440007
  • CAS. No.99416-99-6
  • Mol. F.C13H14O2
  • Mol. W.202.25 g/mol
  • Stock Status:Custom Synthesis
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Agomelatine Phosphate Salt
Agomelatine Phosphate Salt
  • CAT. No.A440008
  • CAS. No.NA
  • Mol. F.C13H18NO5P
  • Mol. W.299.26 g/mol
  • Stock Status:Custom Synthesis
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N-[2-(7-Methoxy-1-naphthyl)ethyl]formamide-phosphoric acid
N-[2-(7-Methoxy-1-naphthyl)ethyl]formamide-phosphoric acid
  • CAT. No.A440009
  • CAS. No.NA
  • Mol. F.C14H18NO6P
  • Mol. W.327.27 g/mol
  • Stock Status:Custom Synthesis
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Agomelatine Impurity 2
Agomelatine Impurity 2
  • CAT. No.A440010
  • CAS. No.178677-39-9
  • Mol. F.C15H19NO2
  • Mol. W.245.32 g/mol
  • Stock Status:Custom Synthesis
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Agomelatine Impurity 16
Agomelatine Impurity 16
  • CAT. No.A440012
  • CAS. No.138113-08-3
  • Mol. F.C13H11NO
  • Mol. W.197.23 g/mol
  • Stock Status:Instock
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Agomelatine Impurity 5 Hydrochloride
Agomelatine Impurity 5 Hydrochloride
  • CAT. No.A440013
  • CAS. No.139525-77-2
  • Mol. F.C13H16ClNO
  • Mol. W.237.73 g/mol
  • Stock Status:Instock
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Agomelatine Impurity 1
Agomelatine Impurity 1
  • CAT. No.A440014
  • CAS. No.1352139-51-5
  • Mol. F.C15H19NO2
  • Mol. W.245.32 g/mol
  • Stock Status:Custom Synthesis
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Agomelatine Impurity 13
Agomelatine Impurity 13
  • CAT. No.A440015
  • CAS. No.178677-49-1
  • Mol. F.C15H21NO2
  • Mol. W.247.33 g/mol
  • Stock Status:Custom Synthesis
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7-Methoxy-1-Tetralone
7-Methoxy-1-Tetralone
  • CAT. No.A440016
  • CAS. No.6836-19-7
  • Mol. F.C11H1202
  • Mol. W.176.21 g/mol
  • Stock Status:Instock
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Agomelatine Impurity 6
Agomelatine Impurity 6
  • CAT. No.A440017
  • CAS. No.138113-07-2
  • Mol. F.C13H13NO2
  • Mol. W.215.25 g/mol
  • Stock Status:Custom Synthesis
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Agomelatine Impurity 14
Agomelatine Impurity 14
  • CAT. No.A440018
  • CAS. No.6836-22-2
  • Mol. F.C13H12O3
  • Mol. W.216.23 g/mol
  • Stock Status:Instock
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Agomelatine Impurity 3
Agomelatine Impurity 3
  • CAT. No.A440019
  • CAS. No.1385018-58-5
  • Mol. F.C28H29NO3
  • Mol. W.427.53 g/mol
  • Stock Status:Instock
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Agomelatine Impurity 15
Agomelatine Impurity 15
  • CAT. No.A440020
  • CAS. No.1385018-57-4
  • Mol. F.C26H27NO2
  • Mol. W.385.50 g/mol
  • Stock Status:Custom Synthesis
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2-(7-methoxynaphthalen-1-yl)-N-(2-(7-methoxynaphthalen-1-yl)ethyl)acetamide
2-(7-methoxynaphthalen-1-yl)-N-(2-(7-methoxynaphthalen-1-yl)ethyl)acetamide
  • CAT. No.A440021
  • CAS. No.NA
  • Mol. F.C26H25NO3
  • Mol. W.399.48 g/mol
  • Stock Status:Instock
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Agomelatine Impurity 10
Agomelatine Impurity 10
  • CAT. No.A440022
  • CAS. No.148018-62-6
  • Mol. F.C12H13NO
  • Mol. W.187.24 g/mol
  • Stock Status:Instock
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6-methoxy-1,2,3,4-tetrahydronaphthalen-2-ol
6-methoxy-1,2,3,4-tetrahydronaphthalen-2-ol
  • CAT. No.A440023
  • CAS. No.1447-87-6
  • Mol. F.C11H14O2
  • Mol. W.178.23 g/mol
  • Stock Status:Custom Synthesis
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2-(7-methoxynaphthalen-1-yl)-N-(2-(7-methoxynaphthalen-1-yl)ethyl)acetimidamide
2-(7-methoxynaphthalen-1-yl)-N-(2-(7-methoxynaphthalen-1-yl)ethyl)acetimidamide
  • CAT. No.A440024
  • CAS. No.NA
  • Mol. F.C26H26N2O2
  • Mol. W.398.50 g/mol
  • Stock Status:Custom Synthesis
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7-Methoxy-1-naphthalenol
7-Methoxy-1-naphthalenol
  • CAT. No.A440025
  • CAS. No.67247-13-6
  • Mol. F.C11H10O2
  • Mol. W.174.20 g/mol
  • Stock Status:Custom Synthesis
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1,2,3,4-Tetrahydro-7-methoxy-1-naphthalenol 1-Acetate
1,2,3,4-Tetrahydro-7-methoxy-1-naphthalenol 1-Acetate
  • CAT. No.A440026
  • CAS. No.945853-23-6
  • Mol. F.C13H16O3
  • Mol. W.220.26 g/mol
  • Stock Status:Instock
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Agomelatine Impurity 7
Agomelatine Impurity 7
  • CAT. No.A440027
  • CAS. No.1379005-34-1
  • Mol. F.C17H19NO3
  • Mol. W.285.34 g/mol
  • Stock Status:Instock
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1-(2-aminoethyl)-7-methoxy-1,2,3,4-tetrahydronaphthalene
1-(2-aminoethyl)-7-methoxy-1,2,3,4-tetrahydronaphthalene
  • CAT. No.A440028
  • CAS. No.59081-66-2
  • Mol. F.C28H29NO3
  • Mol. W.205.30 g/mol
  • Stock Status:Custom Synthesis
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N-Deacetyl-N-Formyl Agomelatine
N-Deacetyl-N-Formyl Agomelatine
  • CAT. No.A440029
  • CAS. No.138113-05-0
  • Mol. F.C14H15NO2
  • Mol. W.229.27 g/mol
  • Stock Status:Custom Synthesis
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3-(4-Methoxybenzoyl)propionic Acid
3-(4-Methoxybenzoyl)propionic Acid
  • CAT. No.A440030
  • CAS. No.3153-44-4
  • Mol. F.C11H12O4
  • Mol. W.208.21 g/mol
  • Stock Status:Custom Synthesis
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4-(4-methoxyphenyl)butanoic acid
4-(4-methoxyphenyl)butanoic acid
  • CAT. No.A440031
  • CAS. No.4521-28-2
  • Mol. F.C11H14O3
  • Mol. W.194.23 g/mol
  • Stock Status:Custom Synthesis
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Agomelatine Urea
Agomelatine Urea
  • CAT. No.A440032
  • CAS. No.1366181-82-9
  • Mol. F.C16H21N3O3
  • Mol. W.303.36 g/mol
  • Stock Status:Custom Synthesis
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Nitroso-2-(7-methoxy-1-naphthyl)-N-[2-(7-methoxy-1-naphthyl)ethyl]ethylamine
Nitroso-2-(7-methoxy-1-naphthyl)-N-[2-(7-methoxy-1-naphthyl)ethyl]ethylamine
  • CAT. No.A440033
  • CAS. No.NA
  • Mol. F.C26H26N2O3
  • Mol. W.414.50 g/mol
  • Stock Status:Custom Synthesis
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Agomelatine Impurity C
Agomelatine Impurity C
  • CAT. No.A440034
  • CAS. No.1607465-50-8
  • Mol. F.C14H17NO2
  • Mol. W.231.29 g/mol
  • Stock Status:Custom Synthesis
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bis(2-(7-methoxynaphthalen-1-yl)ethyl)amine hydrochloride
bis(2-(7-methoxynaphthalen-1-yl)ethyl)amine hydrochloride
  • CAT. No.A440035
  • CAS. No.1623104-92-6
  • Mol. F.C26H27NO2.HCl
  • Mol. W.421.96 g/mol
  • Stock Status:Instock
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N-Nitroso Agomelatine
N-Nitroso Agomelatine
  • CAT. No.A440036
  • CAS. No.NA
  • Mol. F.C15H16N2O3
  • Mol. W.272.30 g/mol
  • Stock Status:Custom Synthesis
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Agomelatine Impurity 10 Hydrochloride
Agomelatine Impurity 10 Hydrochloride
  • CAT. No.A440037
  • CAS. No.229161-32-4
  • Mol. F.C12H13NO.HCl
  • Mol. W.223.70 g/mol
  • Stock Status:Custom Synthesis
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Agomelatine Impurity 18
Agomelatine Impurity 18
  • CAT. No.A440038
  • CAS. No.1079774-32-5
  • Mol. F.C12H9NO
  • Mol. W.183.21 g/mol
  • Stock Status:Custom Synthesis
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Agomelatine Citric Acid
Agomelatine Citric Acid
  • CAT. No.A440039
  • CAS. No.1403960-81-5
  • Mol. F.C15H17NO2.C6H8O7
  • Mol. W.435.43 g/mol
  • Stock Status:Custom Synthesis
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Agomelatine Hydrochloride
Agomelatine Hydrochloride
  • CAT. No.A440040
  • CAS. No.1176316-99-6
  • Mol. F.C15H17NO2.HCl
  • Mol. W.279.76 g/mol
  • Stock Status:Custom Synthesis
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Agomelatine Impurity I
Agomelatine Impurity I
  • CAT. No.A440041
  • CAS. No.1353100-18-1
  • Mol. F.C13H18ClNO
  • Mol. W.239.74 g/mol
  • Stock Status:Custom Synthesis
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Agomelatine Impurity 4
Agomelatine Impurity 4
  • CAT. No.A440042
  • CAS. No.NA
  • Mol. F.C13H15NO
  • Mol. W.201.26 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Agomelatine D6
Agomelatine D6
  • CAT. No.A440003
  • CAS. No.1079389-42-6
  • Mol. F.C15H11D6NO2
  • Mol. W.249.34 g/mol
  • Stock Status:Instock
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3-Hydroxy agomelatine D3
3-Hydroxy agomelatine D3
  • CAT. No.A440011
  • CAS. No.1079774-23-4
  • Mol. F.C15H14D3NO3
  • Mol. W.262.32 g/mol
  • Stock Status:Custom Synthesis
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