Apalutamide Related Compounds & Impurities

Apalutamide is a selective androgen receptor antagonist that blocks receptor translocation and DNA binding, used for non-metastatic and metastatic castration-resistant prostate cancer.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Apalutamide reference standards, pharmacopeial and non-pharmacopeial Apalutamide impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Apalutamide-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Apalutamide
Apalutamide
  • CAT. No.A1660000
  • CAS. No.956104-40-8
  • Mol. F.C21H15F4N5O2S
  • Mol. W.477.44 g/mol
  • Stock Status:Instock
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Apalutamide Des methyl impurity
Apalutamide Des methyl impurity
  • CAT. No.A1660001
  • CAS. No.1332391-11-3
  • Mol. F.C20H13F4N5O2S
  • Mol. W.463.41 g/mol
  • Stock Status:Limited Stock
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Apalutamide Desfluoro Impurity
Apalutamide Desfluoro Impurity
  • CAT. No.A1660003
  • CAS. No.1332389-57-7
  • Mol. F.C21H16F3N5O2S
  • Mol. W.459.44 g/mol
  • Stock Status:Instock
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6,8-Dioxo Apalutamide
6,8-Dioxo Apalutamide
  • CAT. No.A1660005
  • CAS. No.1332391-92-0
  • Mol. F.C21H15F4N5O3
  • Mol. W.461.37 g/mol
  • Stock Status:Instock
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Apalutamide Impurity 2
Apalutamide Impurity 2
  • CAT. No.A1660006
  • CAS. No.NA
  • Mol. F.C21H17F4N5O3S
  • Mol. W.495.45 g/mol
  • Stock Status:Instock
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Apalutamide Dithio Impurity
Apalutamide Dithio Impurity
  • CAT. No.A1660007
  • CAS. No.2649802-40-2
  • Mol. F.C21H15F4N5OS2
  • Mol. W.493.50 g/mol
  • Stock Status:Instock
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Apalutamide Acid Impurity
Apalutamide Acid Impurity
  • CAT. No.A1660008
  • CAS. No.1332391-04-4
  • Mol. F.C20H12F4N4O3S
  • Mol. W.464.39 g/mol
  • Stock Status:Limited Stock
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Apalutamide N-Oxide
Apalutamide N-Oxide
  • CAT. No.A1660009
  • CAS. No.NA
  • Mol. F.C21H15F4N5O3S
  • Mol. W.493.43 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Impurity 7
Apalutamide Impurity 7
  • CAT. No.A1660011
  • CAS. No.2227589-22-0
  • Mol. F.C13H15FN2O3
  • Mol. W.266.27 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Impurity 3
Apalutamide Impurity 3
  • CAT. No.A1660012
  • CAS. No.1950587-20-8
  • Mol. F.C20H17F4N5O2
  • Mol. W.435.37 g/mol
  • Stock Status:Custom Synthesis
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5-(5-(3-fluoro-4-(methylcarbamoyl)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinic acid
5-(5-(3-fluoro-4-(methylcarbamoyl)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinic acid
  • CAT. No.A1660013
  • CAS. No.NA
  • Mol. F.C21H16F4N4O4S
  • Mol. W.496.43 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Amine Impurity
Apalutamide Amine Impurity
  • CAT. No.A1660014
  • CAS. No.915087-26-2
  • Mol. F.C13H14FN3O
  • Mol. W.247.27 g/mol
  • Stock Status:Instock
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Apalutamide Impurity 5
Apalutamide Impurity 5
  • CAT. No.A1660015
  • CAS. No.NA
  • Mol. F.C40H27F8N9O4S
  • Mol. W.881.75 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Impurity 6
Apalutamide Impurity 6
  • CAT. No.A1660016
  • CAS. No.NA
  • Mol. F.C28H19F4N5O3S2
  • Mol. W.613.61 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Impurity 10
Apalutamide Impurity 10
  • CAT. No.A1660017
  • CAS. No.573762-62-6
  • Mol. F.C7H4F3N3
  • Mol. W.187.12 g/mol
  • Stock Status:Instock
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Apalutamide Impurity 13
Apalutamide Impurity 13
  • CAT. No.A1660018
  • CAS. No.956104-42-0
  • Mol. F.C6H2BrF3N2O2
  • Mol. W.270.99 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Impurity 11
Apalutamide Impurity 11
  • CAT. No.A1660019
  • CAS. No.573762-57-9
  • Mol. F.C7H2F3N3O2
  • Mol. W.217.11 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Impurity 19
Apalutamide Impurity 19
  • CAT. No.A1660022
  • CAS. No.1950587-19-5
  • Mol. F.C21H14F4N4O3S
  • Mol. W.478.42 g/mol
  • Stock Status:Instock
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Apalutamide Impurity 20
Apalutamide Impurity 20
  • CAT. No.A1660023
  • CAS. No.1332388-83-6
  • Mol. F.C22H16F4N4O3S
  • Mol. W.492.45 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Thioamide
Apalutamide Thioamide
  • CAT. No.A1660024
  • CAS. No.2422147-84-8
  • Mol. F.C8H5F3N4S
  • Mol. W.246.21 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Oxamide
Apalutamide Oxamide
  • CAT. No.A1660025
  • CAS. No.NA
  • Mol. F.C8H5F3N4O
  • Mol. W.230.15 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Marker Sample
Apalutamide Marker Sample
  • CAT. No.A1660027
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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N-Nitroso Apalutamide Amine Impurity
N-Nitroso Apalutamide Amine Impurity
  • CAT. No.A1660028
  • CAS. No.NA
  • Mol. F.C13H13FN4O2
  • Mol. W.276.27 g/mol
  • Stock Status:Custom Synthesis
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5-(Hydroxyamino)-3-(trifluoromethyl)picolinonitrile
5-(Hydroxyamino)-3-(trifluoromethyl)picolinonitrile
  • CAT. No.A1660029
  • CAS. No.NA
  • Mol. F.C7H4F3N3O
  • Mol. W.203.12 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Impurity 15
Apalutamide Impurity 15
  • CAT. No.A1660030
  • CAS. No.403-24-7
  • Mol. F.C7H4FNO4
  • Mol. W.185.11 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Impurity 4
Apalutamide Impurity 4
  • CAT. No.A1660031
  • CAS. No.NA
  • Mol. F.C29H21F5N6O3S
  • Mol. W.628.57 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Impurity 22
Apalutamide Impurity 22
  • CAT. No.A1660032
  • CAS. No.1950587-21-9
  • Mol. F.C8H2F3N3O
  • Mol. W.213.10 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Impurity 23
Apalutamide Impurity 23
  • CAT. No.A1660033
  • CAS. No.3031093-12-3
  • Mol. F.C15H6F6N6O
  • Mol. W.400.20 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Impurity 24
Apalutamide Impurity 24
  • CAT. No.A1660034
  • CAS. No.2949499-02-7
  • Mol. F.C15H6F6N6S
  • Mol. W.416.30 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Form A
Apalutamide Form A
  • CAT. No.A1660035
  • CAS. No.956104-40-8
  • Mol. F.C21H15F4N5O2S
  • Mol. W.477.44 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Form C
Apalutamide Form C
  • CAT. No.A1660036
  • CAS. No.956104-40-8
  • Mol. F.C21H15F4N5O2S
  • Mol. W.477.44 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Form D
Apalutamide Form D
  • CAT. No.A1660037
  • CAS. No.956104-40-8
  • Mol. F.C21H15F4N5O2S
  • Mol. W.477.44 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Apalutamide Impurity 3
N-Nitroso Apalutamide Impurity 3
  • CAT. No.A1660038
  • CAS. No.NA
  • Mol. F.C13H14FN3O4
  • Mol. W.295.30 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Nitroso Impurity 3
Apalutamide Nitroso Impurity 3
  • CAT. No.A1660039
  • CAS. No.NA
  • Mol. F.C16H18FN3O4
  • Mol. W.335.33 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Apalutamide
N-Nitroso Apalutamide
  • CAT. No.A1660040
  • CAS. No.NA
  • Mol. F.C21H14F4N6O3S
  • Mol. W.506.43 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Apalutamide Impurity 1
N-Nitroso Apalutamide Impurity 1
  • CAT. No.A1660041
  • CAS. No.NA
  • Mol. F.C8H8FN3O2
  • Mol. W.197.17 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Apalutamide Impurity 2
N-Nitroso Apalutamide Impurity 2
  • CAT. No.A1660042
  • CAS. No.NA
  • Mol. F.C7H3F3N4O
  • Mol. W.216.12 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Nitroso Impurity 4
Apalutamide Nitroso Impurity 4
  • CAT. No.A1660043
  • CAS. No.NA
  • Mol. F.C14H16FN3O4
  • Mol. W.309.29 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Impurity 27
Apalutamide Impurity 27
  • CAT. No.A1660045
  • CAS. No.2408380-70-9
  • Mol. F.C13H15FN2O3.C6H15N
  • Mol. W.367.46 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Methyl Ester Impurity
Apalutamide Methyl Ester Impurity
  • CAT. No.A1660046
  • CAS. No.2227589-23-1
  • Mol. F.C14H17FN2O3
  • Mol. W.280.30 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide N-Formyl Impurity
Apalutamide N-Formyl Impurity
  • CAT. No.A1660047
  • CAS. No.NA
  • Mol. F.C21H17F4N5O3
  • Mol. W.463.40 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Impurity 26
Apalutamide Impurity 26
  • CAT. No.A1660048
  • CAS. No.NA
  • Mol. F.C14H15FN2O4
  • Mol. W.294.30 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Impurity 8
Apalutamide Impurity 8
  • CAT. No.A1660049
  • CAS. No.NA
  • Mol. F.C8H8FN3O2
  • Mol. W.197.17 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Impurity 1
Apalutamide Impurity 1
  • CAT. No.A1660050
  • CAS. No.33582-68-2
  • Mol. F.C6H10N2O2
  • Mol. W.142.16 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide Impurity 9
Apalutamide Impurity 9
  • CAT. No.A1660051
  • CAS. No.89691-88-3
  • Mol. F.C6H8N2O2
  • Mol. W.140.14 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

2-fluoro-4-(hydroxyamino)-N-methylbenzamide
2-fluoro-4-(hydroxyamino)-N-methylbenzamide
  • CAT. No.A1660020
  • CAS. No.NA
  • Mol. F.C8H9FN2O2
  • Mol. W.184.17 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Apalutamide 13CD3
Apalutamide 13CD3
  • CAT. No.A1660002
  • CAS. No.956104-40-8(Unlabelled)
  • Mol. F.C2013CH12D3F4N5O2S
  • Mol. W.481.45 g/mol
  • Stock Status:Custom Synthesis
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N-Desmethyl Apalutamide-D4
N-Desmethyl Apalutamide-D4
  • CAT. No.A1660010
  • CAS. No.1332391-11-3(unlabelled)
  • Mol. F.C20H9D4F4N5O2S
  • Mol. W.467.43 g/mol
  • Stock Status:Custom Synthesis
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[13C2,15N]-N-Desmethyl Apalutamide
[13C2,15N]-N-Desmethyl Apalutamide
  • CAT. No.A1660021
  • CAS. No.NA
  • Mol. F.13C2C18H13F4N415NO2S
  • Mol. W.466.39 g/mol
  • Stock Status:Custom Synthesis
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Apalutamide D4
Apalutamide D4
  • CAT. No.A1660026
  • CAS. No.1638885-65-0
  • Mol. F.C21H11D4F4N5O2S
  • Mol. W.481.46 g/mol
  • Stock Status:Instock
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Apalutamide D7
Apalutamide D7
  • CAT. No.A1660044
  • CAS. No.956104-40-8 (Unlabelled)
  • Mol. F.C21H8D7F4N5O2S
  • Mol. W.484.48 g/mol
  • Stock Status:Custom Synthesis
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