Cyclosporine Related Compounds & Impurities

Cyclosporine (ciclosporin) is a cyclic 11-amino-acid undecapeptide calcineurin inhibitor that suppresses T-lymphocyte IL-2 production, used in solid-organ transplantation, bone-marrow transplantation and autoimmune conditions.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Cyclosporine reference standards, pharmacopeial and non-pharmacopeial Cyclosporine impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Cyclosporine-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Cyclosporin
Cyclosporin
  • CAT. No.C090000
  • CAS. No.59865-13-3
  • Mol. F.C62H111N11O12
  • Mol. W.1202.64 g/mol
  • Stock Status:Instock
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Cyclosporin Impurity A
Cyclosporin Impurity A
  • CAT. No.C090001
  • CAS. No.121584-52-9
  • Mol. F.C62H109N11O14
  • Mol. W.1232.60 g/mol
  • Stock Status:Instock
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Cyclosporin Impurity B
Cyclosporin Impurity B
  • CAT. No.C090002
  • CAS. No.63775-95-1
  • Mol. F.C61H109N11O12
  • Mol. W.1188.58 g/mol
  • Stock Status:Limited Stock
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Cyclosporin Impurity C
Cyclosporin Impurity C
  • CAT. No.C090003
  • CAS. No.59787-61-0
  • Mol. F.C62H111N11O13
  • Mol. W.1218.63 g/mol
  • Stock Status:Instock
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Cyclosporine Impurity D
Cyclosporine Impurity D
  • CAT. No.C090004
  • CAS. No.63775-96-2
  • Mol. F.C63H113N11O12
  • Mol. W.1216.66 g/mol
  • Stock Status:Limited Stock
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Cyclosporine Impurity H
Cyclosporine Impurity H
  • CAT. No.C090005
  • CAS. No.83602-39-5
  • Mol. F.C62H111N11O12
  • Mol. W.1202.61 g/mol
  • Stock Status:Limited Stock
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Isocyclosporin A
Isocyclosporin A
  • CAT. No.C090006
  • CAS. No.59865-16-6
  • Mol. F.C62H111N11O12
  • Mol. W.1202.61 g/mol
  • Stock Status:Instock
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Cyclosporin EP Impurity B
Cyclosporin EP Impurity B
  • CAT. No.C090007
  • CAS. No.59865-15-5
  • Mol. F.C62H113N11O12
  • Mol. W.1204.63 g/mol
  • Stock Status:Instock
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Iso Cyclosporin H Ditrifluoroacetate
Iso Cyclosporin H Ditrifluoroacetate
  • CAT. No.C090009
  • CAS. No.83602-43-1(base)
  • Mol. F.C62H111N11O122(C2HF3O2)
  • Mol. W.1430.66 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporin G
Cyclosporin G
  • CAT. No.C090010
  • CAS. No.74436-00-3
  • Mol. F.C63H113N11O12
  • Mol. W.1216.67 g/mol
  • Stock Status:Under Synthesis
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Cyclosporin E
Cyclosporin E
  • CAT. No.C090012
  • CAS. No.63798-73-2
  • Mol. F.C61H109N11O12
  • Mol. W.1188.59 g/mol
  • Stock Status:Limited Stock
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Iso Cyclosporin H Trifluoroacetic Acid Salt
Iso Cyclosporin H Trifluoroacetic Acid Salt
  • CAT. No.C090013
  • CAS. No.83602-43-1(freeamine)
  • Mol. F.C62H111N11O12.C2HF3O2
  • Mol. W.1316.63 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporine U
Cyclosporine U
  • CAT. No.C090014
  • CAS. No.108027-45-8
  • Mol. F.C61H109N11O12
  • Mol. W.1188.61 g/mol
  • Stock Status:Limited Stock
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Cyclosporine-L
Cyclosporine-L
  • CAT. No.C090015
  • CAS. No.108027-39-0
  • Mol. F.C61H109N11O12
  • Mol. W.1188.58 g/mol
  • Stock Status:Instock
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Isocyclosporin H
Isocyclosporin H
  • CAT. No.C090016
  • CAS. No.83602-43-1
  • Mol. F.C62H111N11O12
  • Mol. W.1202.64 g/mol
  • Stock Status:Under Synthesis
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Cyclosporin V
Cyclosporin V
  • CAT. No.C090017
  • CAS. No.108027-46-9
  • Mol. F.C63H113N11O12
  • Mol. W.1216.70 g/mol
  • Stock Status:Custom Synthesis
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Acetyl Voclosporin
Acetyl Voclosporin
  • CAT. No.C090018
  • CAS. No.515814-02-5
  • Mol. F.C65H113N11O13
  • Mol. W.1256.68 g/mol
  • Stock Status:Custom Synthesis
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Clotrimazole Impurity 8
Clotrimazole Impurity 8
  • CAT. No.C090019
  • CAS. No.NA
  • Mol. F.C63H109N11O11
  • Mol. W.1196.61 g/mol
  • Stock Status:Custom Synthesis
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(3S,6S,9S,12R,15S,18S,21S,24S,30S,E)-30-ethyl-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-33-((R,Z)-2-methylhepta-4,6-dien-1-ylidene)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
(3S,6S,9S,12R,15S,18S,21S,24S,30S,E)-30-ethyl-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-33-((R,Z)-2-methylhepta-4,6-dien-1-ylidene)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
  • CAT. No.C090020
  • CAS. No.NA
  • Mol. F.C63H109N11O11
  • Mol. W.1196.61 g/mol
  • Stock Status:Custom Synthesis
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Voclosporin V
Voclosporin V
  • CAT. No.C090021
  • CAS. No.NA
  • Mol. F.C64H113N11O12
  • Mol. W.1228.65 g/mol
  • Stock Status:Custom Synthesis
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Dehydro Cyclosporin
Dehydro Cyclosporin
  • CAT. No.C090022
  • CAS. No.NA
  • Mol. F.C63H109N11O11
  • Mol. W.1196.61 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporin Impurity EP F
Cyclosporin Impurity EP F
  • CAT. No.C090023
  • CAS. No.NA
  • Mol. F.C62H111N11O12
  • Mol. W.1202.61 g/mol
  • Stock Status:Custom Synthesis
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Abu 5-Cyclosporin
Abu 5-Cyclosporin
  • CAT. No.C090024
  • CAS. No.437611-17-1
  • Mol. F.C61H109N11O12
  • Mol. W.1188.58 g/mol
  • Stock Status:Custom Synthesis
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[MeAla]10-CsA
[MeAla]10-CsA
  • CAT. No.C090025
  • CAS. No.NA
  • Mol. F.C59H105N11O12
  • Mol. W.1160.50 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporin Impurity 2
Cyclosporin Impurity 2
  • CAT. No.C090026
  • CAS. No.1907654-63-0
  • Mol. F.C58H103N11O12
  • Mol. W.1146.50 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporin T
Cyclosporin T
  • CAT. No.C090027
  • CAS. No.108027-44-7
  • Mol. F.C61H109N11O12
  • Mol. W.1188.61 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Isocyclosporin A
N-Nitroso Isocyclosporin A
  • CAT. No.C090028
  • CAS. No.NA
  • Mol. F.C62H110N12O13
  • Mol. W.1231.61 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporine F
Cyclosporine F
  • CAT. No.C090029
  • CAS. No.83574-28-1
  • Mol. F.C62H111N11O11
  • Mol. W.1186.61 g/mol
  • Stock Status:Instock
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Cyclosporin A Acetate
Cyclosporin A Acetate
  • CAT. No.C090030
  • CAS. No.83602-41-9
  • Mol. F.C64H113N11O13
  • Mol. W.1244.65 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporin AM 1
Cyclosporin AM 1
  • CAT. No.C090031
  • CAS. No.89270-28-0
  • Mol. F.C62H111N11O13
  • Mol. W.1218.61 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporin AM 9
Cyclosporin AM 9
  • CAT. No.C090032
  • CAS. No.89270-25-7
  • Mol. F.C62H111N11O13
  • Mol. W.1218.61 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporin Impurity 3 Sodium
Cyclosporin Impurity 3 Sodium
  • CAT. No.C090033
  • CAS. No.1822575-19-8 (Free base)
  • Mol. F.C7H15NO3.Na
  • Mol. W.183.18 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporin Impurity 4
Cyclosporin Impurity 4
  • CAT. No.C090034
  • CAS. No.122090-69-1
  • Mol. F.C62H111N11O12
  • Mol. W.1202.61 g/mol
  • Stock Status:Custom Synthesis
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(2H12)-Cyclosporin A
(2H12)-Cyclosporin A
  • CAT. No.C090035
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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Cyclosporin AM 4N
Cyclosporin AM 4N
  • CAT. No.C090036
  • CAS. No.89270-23-5
  • Mol. F.C61H109N11O12
  • Mol. W.1188.59 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporine impurity 1
Cyclosporine impurity 1
  • CAT. No.C090038
  • CAS. No.NA
  • Mol. F.C65H113N11O13
  • Mol. W.1256.66 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporine impurity 2
Cyclosporine impurity 2
  • CAT. No.C090039
  • CAS. No.NA
  • Mol. F.C65H117N11O13
  • Mol. W.1260.69 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporine impurity 3
Cyclosporine impurity 3
  • CAT. No.C090040
  • CAS. No.NA
  • Mol. F.C63H109N11O11
  • Mol. W.1196.61 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporine impurity 4
Cyclosporine impurity 4
  • CAT. No.C090041
  • CAS. No.NA
  • Mol. F.C62H109N11O12
  • Mol. W.1200.60 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporine impurity 5
Cyclosporine impurity 5
  • CAT. No.C090042
  • CAS. No.NA
  • Mol. F.C63H111N11O12
  • Mol. W.1214.62 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporine impurity 6
Cyclosporine impurity 6
  • CAT. No.C090043
  • CAS. No.NA
  • Mol. F.C63H109N11O11
  • Mol. W.1196.61 g/mol
  • Stock Status:Custom Synthesis
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Cyclosporine Impurity 7
Cyclosporine Impurity 7
  • CAT. No.C090044
  • CAS. No.NA
  • Mol. F.C62H111N11O12
  • Mol. W.1202.61 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Cyclosporin D4
Cyclosporin D4
  • CAT. No.C090011
  • CAS. No.NA
  • Mol. F.C62H107D4N11O12
  • Mol. W.1206.64 g/mol
  • Stock Status:Instock
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