Clozapine Related Compounds & Impurities

Clozapine is an atypical dibenzodiazepine antipsychotic uniquely effective in treatment-resistant schizophrenia, requiring mandatory haematological monitoring due to its risk of potentially fatal agranulocytosis.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Clozapine reference standards, pharmacopeial and non-pharmacopeial Clozapine impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Clozapine-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Clozapine
Clozapine
  • CAT. No.C480000
  • CAS. No.5786-21-0
  • Mol. F.C18H19ClN4
  • Mol. W.326.82 g/mol
  • Stock Status:Instock
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Clozapine EP impurity C
Clozapine EP impurity C
  • CAT. No.C480001
  • CAS. No.6104-71-8
  • Mol. F.C17H17ClN4
  • Mol. W.312.80 g/mol
  • Stock Status:Instock
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Clozapine N-oxide
Clozapine N-oxide
  • CAT. No.C480002
  • CAS. No.34233-69-7
  • Mol. F.C18H19ClN4O
  • Mol. W.342.82 g/mol
  • Stock Status:Instock
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Clozapine EP impurity D
Clozapine EP impurity D
  • CAT. No.C480003
  • CAS. No.65514-71-8
  • Mol. F.C18H21ClN4O
  • Mol. W.344.84 g/mol
  • Stock Status:Under Synthesis
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Clozapine EP impurity A
Clozapine EP impurity A
  • CAT. No.C480004
  • CAS. No.50892-62-1
  • Mol. F.C13H9ClN2O
  • Mol. W.244.68 g/mol
  • Stock Status:Instock
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Clozapine EP impurity B
Clozapine EP impurity B
  • CAT. No.C480005
  • CAS. No.263366-81-0
  • Mol. F.C30H24Cl2N6
  • Mol. W.539.46 g/mol
  • Stock Status:Instock
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Clozapine Impurity 10
Clozapine Impurity 10
  • CAT. No.C480009
  • CAS. No.NA
  • Mol. F.C15H11ClN2O2
  • Mol. W.286.71 g/mol
  • Stock Status:Custom Synthesis
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Clozapine Impurity 11
Clozapine Impurity 11
  • CAT. No.C480010
  • CAS. No.NA
  • Mol. F.C20H21ClN4O
  • Mol. W.368.86 g/mol
  • Stock Status:Custom Synthesis
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Clozapine Impurity 5
Clozapine Impurity 5
  • CAT. No.C480011
  • CAS. No.60091-87-4
  • Mol. F.C13H9ClN2O4
  • Mol. W.292.67 g/mol
  • Stock Status:Instock
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1,2-Dimethylpiperazine
1,2-Dimethylpiperazine
  • CAT. No.C480012
  • CAS. No.25057-77-6
  • Mol. F.C6H14N2
  • Mol. W.114.19 g/mol
  • Stock Status:Custom Synthesis
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Clozapine Impurity 9
Clozapine Impurity 9
  • CAT. No.C480013
  • CAS. No.89-61-2
  • Mol. F.C6H3Cl2NO2
  • Mol. W.192.00 g/mol
  • Stock Status:Instock
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Deschloro Clozapine
Deschloro Clozapine
  • CAT. No.C480015
  • CAS. No.1977-07-7
  • Mol. F.C18H20N4
  • Mol. W.292.39 g/mol
  • Stock Status:Instock
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Clozapine Impurity 1
Clozapine Impurity 1
  • CAT. No.C480016
  • CAS. No.69414-55-7
  • Mol. F.C13H8Cl2N2O3
  • Mol. W.311.12 g/mol
  • Stock Status:Custom Synthesis
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Clozapine-D8
Clozapine-D8
  • CAT. No.C480017
  • CAS. No.1185053-50-2
  • Mol. F.C18H11D8ClN4
  • Mol. W.334.88 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Clozapine
N-Nitroso Clozapine
  • CAT. No.C480018
  • CAS. No.156632-03-0
  • Mol. F.C18H18ClN5O
  • Mol. W.355.82 g/mol
  • Stock Status:Instock
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N-Nitroso desmethyl Clozapine impurity
N-Nitroso desmethyl Clozapine impurity
  • CAT. No.C480019
  • CAS. No.NA
  • Mol. F.C17H16ClN5O
  • Mol. W.341.79 g/mol
  • Stock Status:Custom Synthesis
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8-Chloro-5-nitroso-5H-dibenzo[b,e][1,4]diazepin-1(10H)-one
8-Chloro-5-nitroso-5H-dibenzo[b,e][1,4]diazepin-1(10H)-one
  • CAT. No.C480020
  • CAS. No.NA
  • Mol. F.C13H8ClN3O2
  • Mol. W.273.67 g/mol
  • Stock Status:Custom Synthesis
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2-((4-chloro-2-nitrophenyl)(nitroso)amino)benzoic acid
2-((4-chloro-2-nitrophenyl)(nitroso)amino)benzoic acid
  • CAT. No.C480021
  • CAS. No.NA
  • Mol. F.C13H8ClN3O5
  • Mol. W.321.67 g/mol
  • Stock Status:Custom Synthesis
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2-((2-amino-4-chlorophenyl)(nitroso)amino)benzoic acid
2-((2-amino-4-chlorophenyl)(nitroso)amino)benzoic acid
  • CAT. No.C480022
  • CAS. No.NA
  • Mol. F.C13H10ClN3O3
  • Mol. W.291.69 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Clozapine EP Impurity B (possibility 1)
N-Nitroso Clozapine EP Impurity B (possibility 1)
  • CAT. No.C480023
  • CAS. No.NA
  • Mol. F.C30H23Cl2N7O
  • Mol. W.568.50 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Clozapine EP Impurity B (possibility 2)
N-Nitroso Clozapine EP Impurity B (possibility 2)
  • CAT. No.C480024
  • CAS. No.NA
  • Mol. F.C30H22Cl2N8O2
  • Mol. W.597.50 g/mol
  • Stock Status:Custom Synthesis
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Clozapine Impurity 2
Clozapine Impurity 2
  • CAT. No.C480025
  • CAS. No.50373-22-3
  • Mol. F.C13H8Cl2N2
  • Mol. W.263.10 g/mol
  • Stock Status:Custom Synthesis
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Clozapine Impurity 4
Clozapine Impurity 4
  • CAT. No.C480027
  • CAS. No.NA
  • Mol. F.C17H15ClN6O2
  • Mol. W.370.79 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

Clozapine Nitroso EP Impurity C
Clozapine Nitroso EP Impurity C
  • CAT. No.C480028
  • CAS. No.NA
  • Mol. F.C17H16ClN5O
  • Mol. W.341.79 g/mol
  • Stock Status:Please Enquire
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Isotope Labelled Compounds

Clozapine-D3
Clozapine-D3
  • CAT. No.C480008
  • CAS. No.1215691-72-7
  • Mol. F.C18H16ClD3N4
  • Mol. W.329.84 g/mol
  • Stock Status:Instock
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Clozapine Impurity 3 D8
Clozapine Impurity 3 D8
  • CAT. No.C480026
  • CAS. No.2733718-84-6
  • Mol. F.C22H17ClD8N4O2
  • Mol. W.420.96 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Clozapine EP Impurity C d8
N-Nitroso Clozapine EP Impurity C d8
  • CAT. No.C480029
  • CAS. No.NA
  • Mol. F.C17H8D8ClN5O
  • Mol. W.349.84 g/mol
  • Stock Status:Custom Synthesis
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