Leuprolide Related Compounds & Impurities

Leuprolide is a GnRH super-agonist that suppresses gonadotropins upon sustained administration, used for prostate cancer, endometriosis and central precocious puberty.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Leuprolide reference standards, pharmacopeial and non-pharmacopeial Leuprolide impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Leuprolide-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Leuprolide Acetate
Leuprolide Acetate
  • CAT. No.L570000
  • CAS. No.74381-53-6
  • Mol. F.C59H84N16O12.C2H4O2
  • Mol. W.1269.45 g/mol
  • Stock Status:Under Synthesis
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Leuprolide
Leuprolide
  • CAT. No.L570000A
  • CAS. No.53714-56-0
  • Mol. F.C59H84N16O12
  • Mol. W.1209.40 g/mol
  • Stock Status:Instock
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Leuprolide EP Impurity B
Leuprolide EP Impurity B
  • CAT. No.L570002
  • CAS. No.112642-11-2
  • Mol. F.C59H84N16O12
  • Mol. W.1209.42 g/mol
  • Stock Status:Limited Stock
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(D-His2)-Leuprolide
(D-His2)-Leuprolide
  • CAT. No.L570002A
  • CAS. No.112642-11-2
  • Mol. F.C59H84N16O12.C2HF3O2
  • Mol. W.1323.42 g/mol
  • Stock Status:Custom Synthesis
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L-Leu-leuprolide
L-Leu-leuprolide
  • CAT. No.L570003
  • CAS. No.NA
  • Mol. F.C59H84N16O12
  • Mol. W.1209.42 g/mol
  • Stock Status:Custom Synthesis
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D-Ser-leuprolide
D-Ser-leuprolide
  • CAT. No.L570004
  • CAS. No.62621-13-0
  • Mol. F.C59H84N16O12
  • Mol. W.1209.40 g/mol
  • Stock Status:Custom Synthesis
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D-Ser-Leuprolide Trifluoroacetate
D-Ser-Leuprolide Trifluoroacetate
  • CAT. No.L570005
  • CAS. No.NA
  • Mol. F.C59H84N16O12.C2HF3O2
  • Mol. W.1323.42 g/mol
  • Stock Status:Custom Synthesis
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Leuprolide EP Impurity C
Leuprolide EP Impurity C
  • CAT. No.L570006
  • CAS. No.54785-87-4
  • Mol. F.C59H84N16O12
  • Mol. W.1209.40 g/mol
  • Stock Status:Limited Stock
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Leuprolide Acetate EP Impurity D
Leuprolide Acetate EP Impurity D
  • CAT. No.L570007
  • CAS. No.1926163-25-8
  • Mol. F.C61H86N16O13
  • Mol. W.1251.46 g/mol
  • Stock Status:Instock
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Leuprolide EP Impurity E
Leuprolide EP Impurity E
  • CAT. No.L570008
  • CAS. No.1926163-23-6
  • Mol. F.C59H84N16O12
  • Mol. W.1209.42 g/mol
  • Stock Status:Instock
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Leuprolide Acetate EP Impurity F
Leuprolide Acetate EP Impurity F
  • CAT. No.L570009
  • CAS. No.1872435-00-1
  • Mol. F.C59H84N16O12
  • Mol. W.1209.40 g/mol
  • Stock Status:Under Synthesis
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Leuprorelin EP Impurity G
Leuprorelin EP Impurity G
  • CAT. No.L570010
  • CAS. No.112710-57-3
  • Mol. F.C59H84N16O12
  • Mol. W.1209.40 g/mol
  • Stock Status:Instock
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Leuprolide Acetate EP Impurity H
Leuprolide Acetate EP Impurity H
  • CAT. No.L570011
  • CAS. No.112710-58-4
  • Mol. F.C59H84N16O12
  • Mol. W.1209.42 g/mol
  • Stock Status:Limited Stock
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Leuprolide Impurity 6
Leuprolide Impurity 6
  • CAT. No.L570013
  • CAS. No.112642-14-5
  • Mol. F.C52H72N14O12
  • Mol. W.1085.23 g/mol
  • Stock Status:Under Synthesis
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L-Leu6,D-Leu7]leuprolide
L-Leu6,D-Leu7]leuprolide
  • CAT. No.L570014
  • CAS. No.112710-58-4
  • Mol. F.C59H84N16O12
  • Mol. W.1209.40 g/mol
  • Stock Status:Custom Synthesis
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[D-pro9]Leuprolide
[D-pro9]Leuprolide
  • CAT. No.L570015
  • CAS. No.NA
  • Mol. F.C59H84N16O12
  • Mol. W.1209.42 g/mol
  • Stock Status:Custom Synthesis
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[D-Trp3,L-Leu6] Leuprolide
[D-Trp3,L-Leu6] Leuprolide
  • CAT. No.L570016
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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[D-Det6,L-Leu6]leuprolide
[D-Det6,L-Leu6]leuprolide
  • CAT. No.L570017
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.3680.12 g/mol
  • Stock Status:Custom Synthesis
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PGlu-His-Trp
PGlu-His-Trp
  • CAT. No.L570018
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Under Synthesis
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[des-Leu7]leuprolide
[des-Leu7]leuprolide
  • CAT. No.L570019
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Under Synthesis
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Glu.1-Leuprolide
Glu.1-Leuprolide
  • CAT. No.L570020
  • CAS. No.NA
  • Mol. F.C59H86N16O13
  • Mol. W.1227.41 g/mol
  • Stock Status:Instock
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[Glu.1,D-ser] Leuprolide
[Glu.1,D-ser] Leuprolide
  • CAT. No.L570021
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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[Glu.1D-His] Leuprolide
[Glu.1D-His] Leuprolide
  • CAT. No.L570022
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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Des-PGLU-leuprolide
Des-PGLU-leuprolide
  • CAT. No.L570023
  • CAS. No.NA
  • Mol. F.C54H79N15O10
  • Mol. W.1098.30 g/mol
  • Stock Status:Custom Synthesis
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Leuprolide impurity 2
Leuprolide impurity 2
  • CAT. No.L570029
  • CAS. No.NA
  • Mol. F.C62H88N16O14.C2HF3O2
  • Mol. W.1395.48 g/mol
  • Stock Status:Custom Synthesis
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Leuprolide impurity 3
Leuprolide impurity 3
  • CAT. No.L570030
  • CAS. No.NA
  • Mol. F.C61H86N16O14.C2HF3O2
  • Mol. W.1363.44 g/mol
  • Stock Status:Custom Synthesis
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Leuprolide impurity 4
Leuprolide impurity 4
  • CAT. No.L570031
  • CAS. No.267878-61-5
  • Mol. F.C56H79N15O10
  • Mol. W.1122.30 g/mol
  • Stock Status:Custom Synthesis
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Leuprolide Mesylate
Leuprolide Mesylate
  • CAT. No.L570034
  • CAS. No.944347-41-5
  • Mol. F.C60H88N16O15S
  • Mol. W.1305.50 g/mol
  • Stock Status:Instock
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(S)-1-((2-((S)-2-((S)-3-(1H-imidazol-4-yl)-2-((S)-5-oxopyrrolidine-2-carboxamido)propanamido)-3-(1H-indol-3-yl)propanamido)acryloyl)-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl)-N-ethylpyrrolidine-2-carboxamideTrifluoroacetic Acid
(S)-1-((2-((S)-2-((S)-3-(1H-imidazol-4-yl)-2-((S)-5-oxopyrrolidine-2-carboxamido)propanamido)-3-(1H-indol-3-yl)propanamido)acryloyl)-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl)-N-ethylpyrrolidine-2-carboxamideTrifluoroacetic Acid
  • CAT. No.L570035
  • CAS. No.NA
  • Mol. F.C59H82N16O11 .C2HF3O2
  • Mol. W.1305.41 g/mol
  • Stock Status:Custom Synthesis
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Des-1,2,3-Leuprolide
Des-1,2,3-Leuprolide
  • CAT. No.L570036
  • CAS. No.202333-85-5
  • Mol. F.C37H62N10O8
  • Mol. W.774.95 g/mol
  • Stock Status:Custom Synthesis
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D His Leuprolide
D His Leuprolide
  • CAT. No.L570037
  • CAS. No.NA
  • Mol. F.C59H84N16O12
  • Mol. W.1209.40 g/mol
  • Stock Status:Custom Synthesis
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[Ser(Ac)]4-Leuprolide,Acetyl Leuprolide
[Ser(Ac)]4-Leuprolide,Acetyl Leuprolide
  • CAT. No.L570039
  • CAS. No.NA
  • Mol. F.C61H86N16O13
  • Mol. W.1251.43 g/mol
  • Stock Status:Custom Synthesis
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D-[Pyr]1-Leuprolide
D-[Pyr]1-Leuprolide
  • CAT. No.L570040
  • CAS. No.NA
  • Mol. F.C59H84N16O12
  • Mol. W.1209.40 g/mol
  • Stock Status:Custom Synthesis
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5-9-Leuprolide
5-9-Leuprolide
  • CAT. No.L570041
  • CAS. No.129244-90-2
  • Mol. F.C34H57N9O6
  • Mol. W.687.89 g/mol
  • Stock Status:Custom Synthesis
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Des-Pyr-Leuprolide
Des-Pyr-Leuprolide
  • CAT. No.L570042
  • CAS. No.NA
  • Mol. F.C54H79N15O10.C2HF3O2
  • Mol. W.1212.32 g/mol
  • Stock Status:Custom Synthesis
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Leuprolide Acetate Impurity J
Leuprolide Acetate Impurity J
  • CAT. No.L570043
  • CAS. No.NA
  • Mol. F.C62H85N17O12.C2HF3O2
  • Mol. W.1374.47 g/mol
  • Stock Status:Custom Synthesis
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Leuprolide Impurity 5
Leuprolide Impurity 5
  • CAT. No.L570047
  • CAS. No.52434-75-0
  • Mol. F.C34H38N8O9
  • Mol. W.702.70 g/mol
  • Stock Status:Custom Synthesis
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Leuprolide Acetate Impurity I
Leuprolide Acetate Impurity I
  • CAT. No.L570048
  • CAS. No.NA
  • Mol. F.C59H84N16O12.2(C2HF3O2)
  • Mol. W.1437.40 g/mol
  • Stock Status:Custom Synthesis
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Leuprolide Acetate EP Impurity G
Leuprolide Acetate EP Impurity G
  • CAT. No.L570049
  • CAS. No.NA
  • Mol. F.C59H84N16O12.C2HF3O2
  • Mol. W.1323.00 g/mol
  • Stock Status:Custom Synthesis
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Leuprolide-d10 Trifluoroacetic Acid Salt
Leuprolide-d10 Trifluoroacetic Acid Salt
  • CAT. No.L570050
  • CAS. No.NA
  • Mol. F.C59H74D10N16O12.C2HF3
  • Mol. W.1333.51 g/mol
  • Stock Status:Custom Synthesis
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L-Leu6-Leuprolide
L-Leu6-Leuprolide
  • CAT. No.L570052
  • CAS. No.NA
  • Mol. F.C59H84N16O12 .X(C2H4O2)
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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5-9-Leuprolide Trifluoroacetate
5-9-Leuprolide Trifluoroacetate
  • CAT. No.L570053
  • CAS. No.129244-90-2 (free base)
  • Mol. F.C34H57N9O6.C2HF3O2
  • Mol. W.801.90 g/mol
  • Stock Status:Custom Synthesis
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Leuprolide Impurity 7
Leuprolide Impurity 7
  • CAT. No.L570054
  • CAS. No.NA
  • Mol. F.C59H84N16O12
  • Mol. W.1209.40 g/mol
  • Stock Status:Custom Synthesis
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Leuprolide Impurity 8
Leuprolide Impurity 8
  • CAT. No.L570055
  • CAS. No.NA
  • Mol. F.C59H82N16O11
  • Mol. W.1191.38 g/mol
  • Stock Status:Custom Synthesis
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Pyr-His-Trp-OH
Pyr-His-Trp-OH
  • CAT. No.L570056
  • CAS. No.NA
  • Mol. F.C22H24N6O5
  • Mol. W.452.46 g/mol
  • Stock Status:Custom Synthesis
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(O Acetyl L Ser) Leuprolide
(O Acetyl L Ser) Leuprolide
  • CAT. No.L570057
  • CAS. No.NA
  • Mol. F.C61H86N16O13
  • Mol. W.1251.46 g/mol
  • Stock Status:Custom Synthesis
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Leuprolide Dimer
Leuprolide Dimer
  • CAT. No.L570058
  • CAS. No.NA
  • Mol. F.C187H286D5N45O59
  • Mol. W.2425.83 g/mol
  • Stock Status:Custom Synthesis
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Leuprolide EP Impurity B Trifluoroacetate
Leuprolide EP Impurity B Trifluoroacetate
  • CAT. No.L570059
  • CAS. No.NA
  • Mol. F.C59H84N16O12.C2HF3O2
  • Mol. W.1323.40 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

PGlu-His-Trp-OH
PGlu-His-Trp-OH
  • CAT. No.L570024
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Leuprolide 13C6
Leuprolide 13C6
  • CAT. No.L570001
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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Leuprolide D10 Trifluoroacetic Acid Salt
Leuprolide D10 Trifluoroacetic Acid Salt
  • CAT. No.L570012
  • CAS. No.2240176-38-7(Unlabelled)
  • Mol. F.C59H74D10N16O12.C2HF3O2
  • Mol. W.1219.46 g/mol
  • Stock Status:Under Synthesis
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Leuprolide-D5
Leuprolide-D5
  • CAT. No.L570038
  • CAS. No.NA
  • Mol. F.C59H79D5N16O12
  • Mol. W.1214.43 g/mol
  • Stock Status:Custom Synthesis
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