Lifitegrast Related Compounds & Impurities

Lifitegrast is a lymphocyte function-associated antigen-1 (LFA-1) antagonist ophthalmic solution used for dry eye disease.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Lifitegrast reference standards, pharmacopeial and non-pharmacopeial Lifitegrast impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Lifitegrast-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Lifitegrast
Lifitegrast
  • CAT. No.L860000
  • CAS. No.1025967-78-5
  • Mol. F.C29H24Cl2N2O7S
  • Mol. W.615.48 g/mol
  • Stock Status:Instock
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Lifitegrast Impurity 31
Lifitegrast Impurity 31
  • CAT. No.L860001
  • CAS. No.NA
  • Mol. F.C14H17Cl2NO2
  • Mol. W.302.20 g/mol
  • Stock Status:Custom Synthesis
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5,7-Dichloro-2-trityl-1,2,3,4-tetrahydro-isoquinoline-6-carboxylic acid
5,7-Dichloro-2-trityl-1,2,3,4-tetrahydro-isoquinoline-6-carboxylic acid
  • CAT. No.L860002
  • CAS. No.1194550-56-5
  • Mol. F.C29H23Cl2NO2
  • Mol. W.488.40 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 18
Lifitegrast Impurity 18
  • CAT. No.L860003
  • CAS. No.NA
  • Mol. F.C10H13NO4S.HCl
  • Mol. W.279.74 g/mol
  • Stock Status:Custom Synthesis
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Ethyl Benzofuran-6-carboxylate
Ethyl Benzofuran-6-carboxylate
  • CAT. No.L860004
  • CAS. No.1289646-90-7
  • Mol. F.C11H10O3
  • Mol. W.162.14 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 12
Lifitegrast Impurity 12
  • CAT. No.L860005
  • CAS. No.77095-51-3
  • Mol. F.C9H6O3
  • Mol. W.162.14 g/mol
  • Stock Status:Instock
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Lifitegrast impurity A Hydrochloride
Lifitegrast impurity A Hydrochloride
  • CAT. No.L860006
  • CAS. No.2271054-95-4
  • Mol. F.C20H20Cl2N2O5S.HCl
  • Mol. W.507.82 g/mol
  • Stock Status:Instock
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Lifitegrast Impurity 7
Lifitegrast Impurity 7
  • CAT. No.L860007
  • CAS. No.2295862-00-7
  • Mol. F.C29H26N2O7S
  • Mol. W.546.59 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Ethyl Ester Impurity
Lifitegrast Ethyl Ester Impurity
  • CAT. No.L860008
  • CAS. No.2295862-24-5
  • Mol. F.C31H28Cl2N2O7S
  • Mol. W.643.54 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity F
Lifitegrast Impurity F
  • CAT. No.L860009
  • CAS. No.NA
  • Mol. F.C36H30Cl2N2O7S
  • Mol. W.705.6 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 10
Lifitegrast Impurity 10
  • CAT. No.L860010
  • CAS. No.2295862-29-0
  • Mol. F.C30H26Cl2N2O7S
  • Mol. W.629.51 g/mol
  • Stock Status:Instock
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Lifitegrast impurity B
Lifitegrast impurity B
  • CAT. No.L860011
  • CAS. No.NA
  • Mol. F.C22H22Cl2N2O6S
  • Mol. W.513.39 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 1
Lifitegrast Impurity 1
  • CAT. No.L860012
  • CAS. No.1194550-61-2
  • Mol. F.C32H34Cl2N2O7S
  • Mol. W.661.59 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 2 Hydrochloride
Lifitegrast Impurity 2 Hydrochloride
  • CAT. No.L860013
  • CAS. No.1194550-65-6
  • Mol. F.C27H27Cl3N2O5S
  • Mol. W.597.94 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 3
Lifitegrast Impurity 3
  • CAT. No.L860014
  • CAS. No.1194550-67-8
  • Mol. F.C36H30Cl2N2O7S
  • Mol. W.705.60 g/mol
  • Stock Status:Custom Synthesis
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Benzyl (R)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride
Benzyl (R)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride
  • CAT. No.L860015
  • CAS. No.2049127-88-8
  • Mol. F.C17H19NO4S.HCl
  • Mol. W.369.86 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast-R-Isomer
Lifitegrast-R-Isomer
  • CAT. No.L860020
  • CAS. No.2271299-08-0
  • Mol. F.C29H24Cl2N2O7S
  • Mol. W.615.50 g/mol
  • Stock Status:Instock
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Lifitegrast Impurity 2
Lifitegrast Impurity 2
  • CAT. No.L860021
  • CAS. No.NA
  • Mol. F.C15H17BrClNO4
  • Mol. W.390.66 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 1
Lifitegrast Impurity 1
  • CAT. No.L860022
  • CAS. No.NA
  • Mol. F.C15H17BrClNO4
  • Mol. W.390.66 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 3
Lifitegrast Impurity 3
  • CAT. No.L860023
  • CAS. No.NA
  • Mol. F.C29H24BrClN2O7S
  • Mol. W.659.93 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 4
Lifitegrast Impurity 4
  • CAT. No.L860024
  • CAS. No.NA
  • Mol. F.C29H24BrClN2O7S
  • Mol. W.659.93 g/mol
  • Stock Status:Custom Synthesis
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(S)-2-(2-(benzofuran-6-carbonyl)-5-chloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid
(S)-2-(2-(benzofuran-6-carbonyl)-5-chloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid
  • CAT. No.L860025
  • CAS. No.NA
  • Mol. F.C29H25ClN2O7S
  • Mol. W.581.04 g/mol
  • Stock Status:Custom Synthesis
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(S)-2-(2-(benzofuran-6-carbonyl)-7-chloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid
(S)-2-(2-(benzofuran-6-carbonyl)-7-chloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid
  • CAT. No.L860026
  • CAS. No.NA
  • Mol. F.C29H25ClN2O7S
  • Mol. W.581.04 g/mol
  • Stock Status:Custom Synthesis
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(S)-2-(2-(benzofuran-6-carbonyl)-5, 7-dichloro-1,2-dihydroisoquinoline-6-carboxamido )-3-(3-(methylsulfonyl)phenyl)propanoic acid
(S)-2-(2-(benzofuran-6-carbonyl)-5, 7-dichloro-1,2-dihydroisoquinoline-6-carboxamido )-3-(3-(methylsulfonyl)phenyl)propanoic acid
  • CAT. No.L860027
  • CAS. No.NA
  • Mol. F.C29H22Cl2N2O7S
  • Mol. W.613.47 g/mol
  • Stock Status:Custom Synthesis
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(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1-oxo1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid
(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1-oxo1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid
  • CAT. No.L860028
  • CAS. No.NA
  • Mol. F.C29H22Cl2N2O8S
  • Mol. W.629.46 g/mol
  • Stock Status:Custom Synthesis
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(S)-2-(2-(benzofuran-6-carbonyl )-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-bromophenyl)propanoic acid
(S)-2-(2-(benzofuran-6-carbonyl )-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-bromophenyl)propanoic acid
  • CAT. No.L860029
  • CAS. No.NA
  • Mol. F.C28H21BrCl2N2O5
  • Mol. W.616.29 g/mol
  • Stock Status:Instock
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(S)-2-((S)-2-(2-(benzofuran-6-carbonyl)5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid
(S)-2-((S)-2-(2-(benzofuran-6-carbonyl)5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid
  • CAT. No.L860030
  • CAS. No.2641788-18-1
  • Mol. F.C39H35Cl2N3O10S2
  • Mol. W.840.75 g/mol
  • Stock Status:Instock
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N-Boc-1,2,3,4-Tetrahydroisoquinoline-6-carboxylic Acid
N-Boc-1,2,3,4-Tetrahydroisoquinoline-6-carboxylic Acid
  • CAT. No.L860031
  • CAS. No.170097-67-3
  • Mol. F.C15H19NO4
  • Mol. W.277.32 g/mol
  • Stock Status:Custom Synthesis
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2-(tert-butoxycarbonyl)-7-chloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid
2-(tert-butoxycarbonyl)-7-chloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid
  • CAT. No.L860032
  • CAS. No.NA
  • Mol. F.C15H18ClNO4
  • Mol. W.311.76 g/mol
  • Stock Status:Custom Synthesis
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2-(tert-butoxycarbonyl)-5-chloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid
2-(tert-butoxycarbonyl)-5-chloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid
  • CAT. No.L860033
  • CAS. No.NA
  • Mol. F.C15H18ClNO4
  • Mol. W.311.76 g/mol
  • Stock Status:Custom Synthesis
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Methyl 5-Chloro- 1,2,3,4 tetrahydroisoquinoline-6-carboxylate-hydrochloride
Methyl 5-Chloro- 1,2,3,4 tetrahydroisoquinoline-6-carboxylate-hydrochloride
  • CAT. No.L860034
  • CAS. No.NA
  • Mol. F.C11H13Cl2NO2
  • Mol. W.262.13 g/mol
  • Stock Status:Custom Synthesis
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Methyl 7-Chloro- 1,2,3,4 tetrahydroisoquinoline-6-carboxylate-hydrochloride
Methyl 7-Chloro- 1,2,3,4 tetrahydroisoquinoline-6-carboxylate-hydrochloride
  • CAT. No.L860035
  • CAS. No.NA
  • Mol. F.C11H13Cl2NO2
  • Mol. W.262.13 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 14
Lifitegrast Impurity 14
  • CAT. No.L860036
  • CAS. No.2129597-34-6
  • Mol. F.C19H13Cl2NO4
  • Mol. W.390.22 g/mol
  • Stock Status:Instock
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Lifitegrast Impurity 15
Lifitegrast Impurity 15
  • CAT. No.L860037
  • CAS. No.2414639-05-5
  • Mol. F.C33H32Cl2N2O7S
  • Mol. W.671.59 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 8
Lifitegrast Impurity 8
  • CAT. No.L860038
  • CAS. No.1289646-93-0
  • Mol. F.C10H10Cl3NO2
  • Mol. W.282.55 g/mol
  • Stock Status:Instock
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(S)-methyl2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride
(S)-methyl2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride
  • CAT. No.L860039
  • CAS. No.NA
  • Mol. F.C21H22Cl2N2O5S.HCl
  • Mol. W.521.84 g/mol
  • Stock Status:Custom Synthesis
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(S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoic acid
(S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoic acid
  • CAT. No.L860040
  • CAS. No.1270093-99-6
  • Mol. F.C10H13NO4S
  • Mol. W.243.28 g/mol
  • Stock Status:Custom Synthesis
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2-(1-benzofuran-7-ylcarbonl)5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid
2-(1-benzofuran-7-ylcarbonl)5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid
  • CAT. No.L860041
  • CAS. No.NA
  • Mol. F.C19H13Cl2NO4
  • Mol. W.390.22 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 19
Lifitegrast Impurity 19
  • CAT. No.L860042
  • CAS. No.NA
  • Mol. F.C29H24Cl2N2O8S
  • Mol. W.631.48 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 20
Lifitegrast Impurity 20
  • CAT. No.L860043
  • CAS. No.NA
  • Mol. F.C62H54Cl6N4O12S2
  • Mol. W.1323.96 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 9
Lifitegrast Impurity 9
  • CAT. No.L860044
  • CAS. No.NA
  • Mol. F.C19H17NO6S
  • Mol. W.387.41 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 21 Hydrochloride
Lifitegrast Impurity 21 Hydrochloride
  • CAT. No.L860045
  • CAS. No.851785-21-2
  • Mol. F.C11H15NO4S.HCl
  • Mol. W.293.77 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 26
Lifitegrast Impurity 26
  • CAT. No.L860046
  • CAS. No.NA
  • Mol. F.C10H8Cl2N2O3
  • Mol. W.275.09 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 27
Lifitegrast Impurity 27
  • CAT. No.L860047
  • CAS. No.89315-56-0
  • Mol. F.C9H9Cl2N
  • Mol. W.202.08 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 27 Hydrochloride
Lifitegrast Impurity 27 Hydrochloride
  • CAT. No.L860048
  • CAS. No.73075-47-5
  • Mol. F.C9H9Cl2N.HCl
  • Mol. W.238.54 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 28
Lifitegrast Impurity 28
  • CAT. No.L860049
  • CAS. No.1289646-72-5
  • Mol. F.C28H23Cl2N
  • Mol. W.444.40 g/mol
  • Stock Status:Custom Synthesis
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Hydroxy Lifitegrast
Hydroxy Lifitegrast
  • CAT. No.L860050
  • CAS. No.NA
  • Mol. F.C29H24Cl2N2O8S
  • Mol. W.631.48 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 5
Lifitegrast Impurity 5
  • CAT. No.L860051
  • CAS. No.NA
  • Mol. F.C28H24Cl2N2O8S
  • Mol. W.619.47 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Hydroxy Impurity
Lifitegrast Hydroxy Impurity
  • CAT. No.L860052
  • CAS. No.NA
  • Mol. F.C29H24Cl2N2O8S
  • Mol. W.631.48 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 29
Lifitegrast Impurity 29
  • CAT. No.L860053
  • CAS. No.NA
  • Mol. F.C29H24Cl2N2O8S
  • Mol. W.631.48 g/mol
  • Stock Status:Custom Synthesis
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Lifitigrast Nitrosamine Impurity
Lifitigrast Nitrosamine Impurity
  • CAT. No.L860054
  • CAS. No.NA
  • Mol. F.C20H19Cl2N3O6S
  • Mol. W.500.35 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 11
Lifitegrast Impurity 11
  • CAT. No.L860055
  • CAS. No.NA
  • Mol. F.C29H24BrClN2O7S
  • Mol. W.659.93 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 6
Lifitegrast Impurity 6
  • CAT. No.L860056
  • CAS. No.NA
  • Mol. F.C13H9ClN4
  • Mol. W.508.31 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 13
Lifitegrast Impurity 13
  • CAT. No.L860057
  • CAS. No.2349951-97-7
  • Mol. F.C14H21NO4S
  • Mol. W.299.39 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Nitroso impurity 1
Lifitegrast Nitroso impurity 1
  • CAT. No.L860058
  • CAS. No.NA
  • Mol. F.C29H23Cl2N3O8S
  • Mol. W.644.48 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 16
Lifitegrast Impurity 16
  • CAT. No.L860059
  • CAS. No.90721-27-0
  • Mol. F.C9H6O3
  • Mol. W.162.14 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 17
Lifitegrast Impurity 17
  • CAT. No.L860060
  • CAS. No.90484-22-3
  • Mol. F.C9H6O3
  • Mol. W.162.14 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 22
Lifitegrast Impurity 22
  • CAT. No.L860061
  • CAS. No.3053861-51-8
  • Mol. F.C28H24Cl2N2O9S
  • Mol. W.635.47 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 23
Lifitegrast Impurity 23
  • CAT. No.L860062
  • CAS. No.2260511-33-7
  • Mol. F.C24H15Cl2N5O4
  • Mol. W.508.30 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 24
Lifitegrast Impurity 24
  • CAT. No.L860063
  • CAS. No.NA
  • Mol. F.C10H13NO4S.HCl
  • Mol. W.279.74 g/mol
  • Stock Status:Custom Synthesis
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Lifitegrast Impurity 25
Lifitegrast Impurity 25
  • CAT. No.L860064
  • CAS. No.NA
  • Mol. F.C19H15Cl2NO2
  • Mol. W.438.30 g/mol
  • Stock Status:Custom Synthesis
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