Desloratadine Related Compounds & Impurities

Desloratadine is the pharmacologically active carboxylic-acid metabolite of loratadine and the most potent H1-receptor antihistamine currently in clinical use, providing non-sedating allergy relief for allergic rhinitis and chronic urticaria.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Desloratadine reference standards, pharmacopeial and non-pharmacopeial Desloratadine impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Desloratadine-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Desloratadine
Desloratadine
  • CAT. No.D130000
  • CAS. No.100643-71-8
  • Mol. F.C19H19ClN2
  • Mol. W.310.82 g/mol
  • Stock Status:Instock
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Desloratadine form II
Desloratadine form II
  • CAT. No.D130000A
  • CAS. No.100643-71-8
  • Mol. F.C19H19ClN2
  • Mol. W.310.82 g/mol
  • Stock Status:Instock
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Desloratadine 3-Hydroxy Impurity
Desloratadine 3-Hydroxy Impurity
  • CAT. No.D130001
  • CAS. No.119410-08-1
  • Mol. F.C19H19ClN2O
  • Mol. W.326.82 g/mol
  • Stock Status:Instock
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Desloratadine N-Oxide
Desloratadine N-Oxide
  • CAT. No.D130004
  • CAS. No.169253-26-3
  • Mol. F.C19H19ClN2O
  • Mol. W.326.82g/mol
  • Stock Status:Instock
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Desloratadine Citric Amide Impurity
Desloratadine Citric Amide Impurity
  • CAT. No.D130005
  • CAS. No.1797131-43-1
  • Mol. F.C25H25ClN2O6
  • Mol. W.484.93g/mol
  • Stock Status:Limited Stock
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Desloratadine Impurity A
Desloratadine Impurity A
  • CAT. No.D130006
  • CAS. No.117796-50-6
  • Mol. F.C19H19BrN2
  • Mol. W.355.27 g/mol
  • Stock Status:Under Synthesis
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Desloratadine N-Formyl Impurity
Desloratadine N-Formyl Impurity
  • CAT. No.D130007
  • CAS. No.117810-61-4
  • Mol. F.C20H19ClN2O
  • Mol. W.338.83 g/mol
  • Stock Status:Instock
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Desloratadine N-Hydroxy Impurity
Desloratadine N-Hydroxy Impurity
  • CAT. No.D130008
  • CAS. No.1193725-73-3
  • Mol. F.C19H19ClN2O
  • Mol. W.326.11 g/mol
  • Stock Status:Instock
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Desloratadine EP Impurity A
Desloratadine EP Impurity A
  • CAT. No.D130009
  • CAS. No.298220-99-2
  • Mol. F.C19H20ClFN2
  • Mol. W.330.83 g/mol
  • Stock Status:Under Synthesis
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Desloratadine EP Impurity B
Desloratadine EP Impurity B
  • CAT. No.D130010
  • CAS. No.183198-49-4
  • Mol. F.C19H19ClN2
  • Mol. W.310.82 g/mol
  • Stock Status:Instock
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Desloratidine EP Impurity B Hydrochloride
Desloratidine EP Impurity B Hydrochloride
  • CAT. No.D130010A
  • CAS. No.432543-89-0
  • Mol. F.C19H19ClN2.HCl
  • Mol. W.347.28 g/mol
  • Stock Status:Custom Synthesis
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Desloratadine Dehydro Impurity
Desloratadine Dehydro Impurity
  • CAT. No.D130012
  • CAS. No.117811-20-8
  • Mol. F.C19H17ClN2
  • Mol. W.308.80 g/mol
  • Stock Status:Under Synthesis
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Desloratadine Deschloro Impurity Hydrochloride
Desloratadine Deschloro Impurity Hydrochloride
  • CAT. No.D130013
  • CAS. No.2172059-46-8
  • Mol. F.C19H20N2.HCl
  • Mol. W.312.84 g/mol
  • Stock Status:Instock
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Desloratadine Deschloro Impurity
Desloratadine Deschloro Impurity
  • CAT. No.D130013A
  • CAS. No.38092-95-4
  • Mol. F.CHN
  • Mol. W.276.38 g/mol
  • Stock Status:Limited Stock
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3-Hydroxy desloratadine glucuronide
3-Hydroxy desloratadine glucuronide
  • CAT. No.D130014
  • CAS. No.774538-89-5
  • Mol. F.C25H27ClN2O7
  • Mol. W.502.96 g/mol
  • Stock Status:Under Synthesis
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4-Chloro-1-methylpiperidine
4-Chloro-1-methylpiperidine
  • CAT. No.D130016
  • CAS. No.5570-77-4
  • Mol. F.C6H12ClN
  • Mol. W.133.61 g/mol
  • Stock Status:Instock
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Desloratadine 11-Hydroxy Impurity
Desloratadine 11-Hydroxy Impurity
  • CAT. No.D130017
  • CAS. No.153200-97-6
  • Mol. F.C19H21ClN2O
  • Mol. W.328.84 g/mol
  • Stock Status:Instock
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Desloratadine Methanone Hydrochloride Impurity
Desloratadine Methanone Hydrochloride Impurity
  • CAT. No.D130018
  • CAS. No.119770-60-4
  • Mol. F.C20H23ClN2O.HCl
  • Mol. W.379.32 g/mol
  • Stock Status:Instock
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Desloratadine Related Compound A
Desloratadine Related Compound A
  • CAT. No.D130019
  • CAS. No.117796-50-6
  • Mol. F.C19H19BrN2
  • Mol. W.355.27 g/mol
  • Stock Status:Instock
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Desloratadine Related Compound B
Desloratadine Related Compound B
  • CAT. No.D130020
  • CAS. No.NA
  • Mol. F.C19H20Cl2N2
  • Mol. W.347.28 g/mol
  • Stock Status:Custom Synthesis
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Desloratadine N-Carboxylic Acid Methyl Ester
Desloratadine N-Carboxylic Acid Methyl Ester
  • CAT. No.D130021
  • CAS. No.165740-03-4
  • Mol. F.C21H21ClN2O2
  • Mol. W.368.86 g/mol
  • Stock Status:Instock
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Desloratadine EP Impurity A
Desloratadine EP Impurity A
  • CAT. No.D130022
  • CAS. No.298220-99-2
  • Mol. F.C19H20ClFN2
  • Mol. W.330.83 g/mol
  • Stock Status:Custom Synthesis
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Desloratadine EP Impurity B
Desloratadine EP Impurity B
  • CAT. No.D130023
  • CAS. No.183198-49-4
  • Mol. F.C19H19ClN2
  • Mol. W.310.82 g/mol
  • Stock Status:Instock
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8,11-dichloro-11-piperidin-4-yl-6-11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
8,11-dichloro-11-piperidin-4-yl-6-11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
  • CAT. No.D130024
  • CAS. No.NA
  • Mol. F.C19H20Cl2N2
  • Mol. W.347.28 g/mol
  • Stock Status:Custom Synthesis
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Desloratadine 8-Bromo-11-Oxo Impurity
Desloratadine 8-Bromo-11-Oxo Impurity
  • CAT. No.D130025
  • CAS. No.143540-56-1
  • Mol. F.C14H10BrNO
  • Mol. W.288.14 g/mol
  • Stock Status:Instock
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Desloratadine Dehydro 11-Oxo Impurity
Desloratadine Dehydro 11-Oxo Impurity
  • CAT. No.D130026
  • CAS. No.117811-16-2
  • Mol. F.C14H8ClNO
  • Mol. W.241.67 g/mol
  • Stock Status:Instock
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8-Deschloro-8-Bromo-N-Methyl Desloratadine
8-Deschloro-8-Bromo-N-Methyl Desloratadine
  • CAT. No.D130027
  • CAS. No.130642-57-8
  • Mol. F.C20H21BrN2
  • Mol. W.369.30 g/mol
  • Stock Status:Instock
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Desloratadine Dehydro N-Methyl Impurity
Desloratadine Dehydro N-Methyl Impurity
  • CAT. No.D130028
  • CAS. No.117811-18-4
  • Mol. F.C20H19ClN2
  • Mol. W.322.83 g/mol
  • Stock Status:Instock
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Desloratadine N-Acetyl Impurity
Desloratadine N-Acetyl Impurity
  • CAT. No.D130029
  • CAS. No.117796-52-8
  • Mol. F.C21H21ClN2O
  • Mol. W.352.86 g/mol
  • Stock Status:Instock
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N-Nitroso Desloratadine
N-Nitroso Desloratadine
  • CAT. No.D130030
  • CAS. No.1246819-22-6
  • Mol. F.C19H18ClN3O
  • Mol. W.339.82 g/mol
  • Stock Status:Instock
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Desloratadine 8-Dechloro-9-Chloro Impurity
Desloratadine 8-Dechloro-9-Chloro Impurity
  • CAT. No.D130031
  • CAS. No.117811-13-9
  • Mol. F.C19H19ClN2
  • Mol. W.310.82 g/mol
  • Stock Status:Custom Synthesis
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8-chloro-11-fluoro-11-(1-methylpiperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]-cyclohepta[1,2-b]pyridine
8-chloro-11-fluoro-11-(1-methylpiperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]-cyclohepta[1,2-b]pyridine
  • CAT. No.D130032
  • CAS. No.125743-81-9
  • Mol. F.C20H22ClFN2
  • Mol. W.344.85 g/mol
  • Stock Status:Custom Synthesis
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3-Hydroxy Desloratadine Glucuronide Sodium Salt
3-Hydroxy Desloratadine Glucuronide Sodium Salt
  • CAT. No.D130034
  • CAS. No.NA
  • Mol. F.C25H26ClN2NaO7
  • Mol. W.524.93 g/mol
  • Stock Status:Custom Synthesis
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8-Dechloro-7-chloro Desloratadine
8-Dechloro-7-chloro Desloratadine
  • CAT. No.D130035
  • CAS. No.1346601-53-3
  • Mol. F.C19H19ClN2
  • Mol. W.310.82 g/mol
  • Stock Status:Custom Synthesis
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8-Dechloro-10-chloro Desloratadine
8-Dechloro-10-chloro Desloratadine
  • CAT. No.D130036
  • CAS. No.1346600-61-0
  • Mol. F.C19H19ClN2
  • Mol. W.310.82 g/mol
  • Stock Status:Custom Synthesis
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8-Dechloro-7-chloro-N-methyl Desloratadine
8-Dechloro-7-chloro-N-methyl Desloratadine
  • CAT. No.D130037
  • CAS. No.1346600-30-3
  • Mol. F.C20H21ClN2
  • Mol. W.324.85 g/mol
  • Stock Status:Custom Synthesis
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Desloratadine Epoxide
Desloratadine Epoxide
  • CAT. No.D130038
  • CAS. No.1346604-23-6
  • Mol. F.C19H19ClN2O
  • Mol. W.326.82 g/mol
  • Stock Status:Custom Synthesis
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8-Dechloro-10-chloro-N-methyl Desloratadine
8-Dechloro-10-chloro-N-methyl Desloratadine
  • CAT. No.D130039
  • CAS. No.38092-90-9
  • Mol. F.C20H21ClN2
  • Mol. W.324.85 g/mol
  • Stock Status:Custom Synthesis
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6-Hydroxy Desloratadine
6-Hydroxy Desloratadine
  • CAT. No.D130040
  • CAS. No.119410-05-8
  • Mol. F.C19H19ClN2O
  • Mol. W.326.82 g/mol
  • Stock Status:Custom Synthesis
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Desloratadine 8-Bromo-11-Hydroxy-N-Methyl Impurity
Desloratadine 8-Bromo-11-Hydroxy-N-Methyl Impurity
  • CAT. No.D130042
  • CAS. No.2648910-20-5
  • Mol. F.C20H23BrN2O
  • Mol. W.387.31 g/mol
  • Stock Status:Instock
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Desloratadine Dehydro N-Methyl Impurity Hydrochloride
Desloratadine Dehydro N-Methyl Impurity Hydrochloride
  • CAT. No.D130043
  • CAS. No.117811-18-4 (free base)
  • Mol. F.C20H19ClN2.HCl
  • Mol. W.359.29 g/mol
  • Stock Status:Custom Synthesis
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Desloratadine Dehydro 11-Hydroxy N-Methyl Impurity
Desloratadine Dehydro 11-Hydroxy N-Methyl Impurity
  • CAT. No.D130044
  • CAS. No.117811-17-3
  • Mol. F.C20H21ClN2O
  • Mol. W.340.85 g/mol
  • Stock Status:Instock
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Desloratadine Form-I
Desloratadine Form-I
  • CAT. No.D130045
  • CAS. No.100643-71-8
  • Mol. F.C19H19ClN2
  • Mol. W.310.82 g/mol
  • Stock Status:Instock
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8-chloro-11-(4-fluoro-1-methylpiperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1.2`b]pyridine
8-chloro-11-(4-fluoro-1-methylpiperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1.2`b]pyridine
  • CAT. No.D130046
  • CAS. No.125743-82-0
  • Mol. F.C20H22ClFN2
  • Mol. W.344.85 g/mol
  • Stock Status:Limited Stock
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Desloratadine Methanone Impurity
Desloratadine Methanone Impurity
  • CAT. No.D130048
  • CAS. No.130642-50-1
  • Mol. F.C20H23ClN2O
  • Mol. W.342.86 g/mol
  • Stock Status:Custom Synthesis
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Desloratadine Carbonitryl Impurity
Desloratadine Carbonitryl Impurity
  • CAT. No.D130049
  • CAS. No.NA
  • Mol. F.C14H11ClN2
  • Mol. W.242.70 g/mol
  • Stock Status:Custom Synthesis
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Desloratadine Impurity 1
Desloratadine Impurity 1
  • CAT. No.D130050
  • CAS. No.NA
  • Mol. F.C20H23ClN2O
  • Mol. W.342.86 g/mol
  • Stock Status:Custom Synthesis
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Desloratadine N-nitroso Methanone Impurity
Desloratadine N-nitroso Methanone Impurity
  • CAT. No.D130051
  • CAS. No.NA
  • Mol. F.C19H26ClN3O2
  • Mol. W.363.88 g/mol
  • Stock Status:Custom Synthesis
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Desloratadine Impurity 2
Desloratadine Impurity 2
  • CAT. No.D130052
  • CAS. No.167891-68-1
  • Mol. F.C19H21ClN2
  • Mol. W.312.84 g/mol
  • Stock Status:Custom Synthesis
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Desloratadine Impurity 3
Desloratadine Impurity 3
  • CAT. No.D130053
  • CAS. No.NA
  • Mol. F.C19H21ClN2O
  • Mol. W.328.84 g/mol
  • Stock Status:Custom Synthesis
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Desloratadine D5 Hydrochloride
Desloratadine D5 Hydrochloride
  • CAT. No.D130054
  • CAS. No.2733146-31-9
  • Mol. F.C19H14D5ClN2.HCl
  • Mol. W.352.31 g/mol
  • Stock Status:Custom Synthesis
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Desloratadine Impurity 4
Desloratadine Impurity 4
  • CAT. No.D130055
  • CAS. No.183198-48-3
  • Mol. F.C20H21ClN2
  • Mol. W.324.80 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Desloratadine-D4
Desloratadine-D4
  • CAT. No.D130002
  • CAS. No.381727-29-3
  • Mol. F.C19H15D4ClN2
  • Mol. W.314.82 g/mol
  • Stock Status:Under Synthesis
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3-Hydroxy Desloratadine-D4
3-Hydroxy Desloratadine-D4
  • CAT. No.D130003
  • CAS. No.1246819-99-7
  • Mol. F.C19H15D4ClN2O
  • Mol. W.330.82 g/mol
  • Stock Status:Instock
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Desloratadine D5
Desloratadine D5
  • CAT. No.D130015
  • CAS. No.1020719-34-9
  • Mol. F.C19H14D5ClN2
  • Mol. W.315.85 g/mol
  • Stock Status:Under Synthesis
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Desloratadine-d1 N-Oxide
Desloratadine-d1 N-Oxide
  • CAT. No.D130033
  • CAS. No.1794817-18-7
  • Mol. F.C19H18DClN2O
  • Mol. W.327.83 g/mol
  • Stock Status:Custom Synthesis
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Desloratadine-D4 Hydrobromide
Desloratadine-D4 Hydrobromide
  • CAT. No.D130041
  • CAS. No.NA
  • Mol. F.C19H16D4BrClN2
  • Mol. W.395.76 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Desloratadine-D4
N-Nitroso Desloratadine-D4
  • CAT. No.D130047
  • CAS. No.2733579-31-0
  • Mol. F.C19H14D4ClN3O
  • Mol. W.343.80 g/mol
  • Stock Status:Custom Synthesis
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