Daptomycin Related Compounds & Impurities

Daptomycin is a cyclic lipopeptide antibiotic that inserts into bacterial membranes in a calcium-dependent manner to cause rapid membrane depolarisation and cell death, used for Gram-positive bacteraemia and right-sided endocarditis.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Daptomycin reference standards, pharmacopeial and non-pharmacopeial Daptomycin impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Daptomycin-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Daptomycin
Daptomycin
  • CAT. No.D690000
  • CAS. No.103060-53-3 
  • Mol. F.C72H101N17O26
  • Mol. W.1620.67 g/mol
  • Stock Status:Instock
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Daptomycin Anhydro Impurity Acetate
Daptomycin Anhydro Impurity Acetate
  • CAT. No.D690001
  • CAS. No.121869-35-0 (free base)
  • Mol. F.C72H99N17O25.C2H4O2
  • Mol. W.1662.71 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin beta-Isomer
Daptomycin beta-Isomer
  • CAT. No.D690002
  • CAS. No.123180-72-3
  • Mol. F.C72H101N17O26
  • Mol. W.1620.67 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Lactone Impurity
Daptomycin Lactone Impurity
  • CAT. No.D690004
  • CAS. No.NA
  • Mol. F.C72H103N17O27
  • Mol. W.1638.69 g/mol
  • Stock Status:Custom Synthesis
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N-decanoyl-L-tryptophyl-Dasparaginyl-L-aspartyl-ethylenglycine-glycyl-Lornithyl-L-aspartyl-D-alanyl-L-aspartyl-glycyl-D-serylthreo-3-methyl-L-glutamyl3-anthraniloyl-L-alanine
N-decanoyl-L-tryptophyl-Dasparaginyl-L-aspartyl-ethylenglycine-glycyl-Lornithyl-L-aspartyl-D-alanyl-L-aspartyl-glycyl-D-serylthreo-3-methyl-L-glutamyl3-anthraniloyl-L-alanine
  • CAT. No.D690005
  • CAS. No.NA
  • Mol. F.C72H101N17O26
  • Mol. W.1620.67 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity 16
Daptomycin Impurity 16
  • CAT. No.D690006
  • CAS. No.NA
  • Mol. F.C71H101N17O27
  • Mol. W.1624.66 g/mol
  • Stock Status:Custom Synthesis
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N-decanoyl-L-tryptophyl-Dasparaginyl-L-aspartyl-Lthreonyl(L-aspartyl-Dalanyl-L-aspartyl-glycyl-Dseryl-threo-3-methyl-L glutamyl-3-anthraniloyl-Lalanineepsilon1-lactone)-glycylL-ornithyne
N-decanoyl-L-tryptophyl-Dasparaginyl-L-aspartyl-Lthreonyl(L-aspartyl-Dalanyl-L-aspartyl-glycyl-Dseryl-threo-3-methyl-L glutamyl-3-anthraniloyl-Lalanineepsilon1-lactone)-glycylL-ornithyne
  • CAT. No.D690007
  • CAS. No.NA
  • Mol. F.C73H105N17O27
  • Mol. W.1652.71 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity 1
Daptomycin Impurity 1
  • CAT. No.D690008
  • CAS. No.NA
  • Mol. F.C73H103N17O26
  • Mol. W.1634.70 g/mol
  • Stock Status:Custom Synthesis
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N-decanoyl-L-tryptophyl-Dasparaginyl-L-aspartyl-Lthreonyl-glycyl-L-ornithyl-L-asparticacid
N-decanoyl-L-tryptophyl-Dasparaginyl-L-aspartyl-Lthreonyl-glycyl-L-ornithyl-L-asparticacid
  • CAT. No.D690009
  • CAS. No.NA
  • Mol. F.C44H66N10O15
  • Mol. W.975.05 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity B2
Daptomycin Impurity B2
  • CAT. No.D690010
  • CAS. No.NA
  • Mol. F.C40H61N9O12
  • Mol. W.859.99 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity D
Daptomycin Impurity D
  • CAT. No.D690011
  • CAS. No.NA
  • Mol. F.C74H103N17O27
  • Mol. W.1662.71 g/mol
  • Stock Status:Custom Synthesis
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2,2`-((3S,6S,15R,18R,21S,24S,30S,31R)-30-((S)-2-((R)-4-Amino-2-((S)-2-decanamido-3-(1H-indol-3-yl)propanamido)-4-oxobutanamido)-3-carboxypropanamido)-3-(2-(2-aminophenyl)-2-oxoethyl)-24-(3-aminopropyl)-6-((S)-1-carboxypropan-2-yl)-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontane-15,21-diyl)diacetic Acid
2,2`-((3S,6S,15R,18R,21S,24S,30S,31R)-30-((S)-2-((R)-4-Amino-2-((S)-2-decanamido-3-(1H-indol-3-yl)propanamido)-4-oxobutanamido)-3-carboxypropanamido)-3-(2-(2-aminophenyl)-2-oxoethyl)-24-(3-aminopropyl)-6-((S)-1-carboxypropan-2-yl)-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontane-15,21-diyl)diacetic Acid
  • CAT. No.D690012
  • CAS. No.NA
  • Mol. F.C72H101N17O26
  • Mol. W.1620.67 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity 19
Daptomycin Impurity 19
  • CAT. No.D690013
  • CAS. No.NA
  • Mol. F.C74H99N17O26
  • Mol. W.1642.70 g/mol
  • Stock Status:Custom Synthesis
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N-decanoyl-L-tryptophyl-Dasparaginyl-L-aspartyl-Lthreonyl-glycyl-L-lysin-Laspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3methyl-L-glutamyl-3anthraniloyl-L-alanine Epsilon1 lactone
N-decanoyl-L-tryptophyl-Dasparaginyl-L-aspartyl-Lthreonyl-glycyl-L-lysin-Laspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3methyl-L-glutamyl-3anthraniloyl-L-alanine Epsilon1 lactone
  • CAT. No.D690014
  • CAS. No.NA
  • Mol. F.C72H101N17O26
  • Mol. W.1620.67 g/mol
  • Stock Status:Custom Synthesis
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N-decanoyl-L-tryptophyl-D asparaginyl-L-aspartyl-Lthreonyl-glycyl-L-ornithylL-aspartyl-L-alanyl-Laspartylglycyl-D-seryl-threo3-methyl-L-glutamyl-3anthraniloyl-D-homoalanylepsilon1-lactone
N-decanoyl-L-tryptophyl-D asparaginyl-L-aspartyl-Lthreonyl-glycyl-L-ornithylL-aspartyl-L-alanyl-Laspartylglycyl-D-seryl-threo3-methyl-L-glutamyl-3anthraniloyl-D-homoalanylepsilon1-lactone
  • CAT. No.D690015
  • CAS. No.NA
  • Mol. F.C73H103N17O26
  • Mol. W.1634.70 g/mol
  • Stock Status:Custom Synthesis
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N-decanoyl-L-tryptophyl-Dasparaginyl-L-aspartyl-Lthreonyl-glycyl-L-ornithylL-succinimmidyl-D-alanylL-aspartylglycyl-D-serylthreo-3-methyl-L-glutamyl3-anthraniloyl-L-alanineepsilon1 lactone
N-decanoyl-L-tryptophyl-Dasparaginyl-L-aspartyl-Lthreonyl-glycyl-L-ornithylL-succinimmidyl-D-alanylL-aspartylglycyl-D-serylthreo-3-methyl-L-glutamyl3-anthraniloyl-L-alanineepsilon1 lactone
  • CAT. No.D690016
  • CAS. No.NA
  • Mol. F.C74H102N16O26
  • Mol. W.1631.69 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Isodecy Acyl Isomer
Daptomycin Isodecy Acyl Isomer
  • CAT. No.D690017
  • CAS. No.NA
  • Mol. F.C72H101N17O26
  • Mol. W.1620.69 g/mol
  • Stock Status:Custom Synthesis
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Hydroxy Derivative of Daptomycin
Hydroxy Derivative of Daptomycin
  • CAT. No.D690018
  • CAS. No.921590-20-7
  • Mol. F.C72H101N17O27
  • Mol. W.1636.70 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity 17
Daptomycin Impurity 17
  • CAT. No.D690019
  • CAS. No.866822-35-7
  • Mol. F.C40H61N9O12
  • Mol. W.859.97 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity 33
Daptomycin Impurity 33
  • CAT. No.D690020
  • CAS. No.NA
  • Mol. F.C72H101N17O26
  • Mol. W.1620.67 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity 34
Daptomycin Impurity 34
  • CAT. No.D690021
  • CAS. No.NA
  • Mol. F.C72H99N17O25
  • Mol. W.1602.66 g/mol
  • Stock Status:Custom Synthesis
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Ethyl Isomer Of Daptomycin
Ethyl Isomer Of Daptomycin
  • CAT. No.D690022
  • CAS. No.NA
  • Mol. F.C73H103N17O26
  • Mol. W.1634.70 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity 35
Daptomycin Impurity 35
  • CAT. No.D690023
  • CAS. No.NA
  • Mol. F.C67H90N16O28
  • Mol. W.1567.52 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity 36
Daptomycin Impurity 36
  • CAT. No.D690024
  • CAS. No.NA
  • Mol. F.C69H94N16O27
  • Mol. W.1579.58 g/mol
  • Stock Status:Custom Synthesis
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Asp-cyclized Daptomycin
Asp-cyclized Daptomycin
  • CAT. No.D690025
  • CAS. No.NA
  • Mol. F.C73H100N16O25
  • Mol. W.1601.70 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Anhydro Impurity
Daptomycin Anhydro Impurity
  • CAT. No.D690026
  • CAS. No.121869-35-0
  • Mol. F.C72H99N17O25
  • Mol. W.1602.70 g/mol
  • Stock Status:Instock
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Daptomycin Impurity 4
Daptomycin Impurity 4
  • CAT. No.D690028
  • CAS. No.NA
  • Mol. F.C44H68N10O14
  • Mol. W.961.07 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity 5
Daptomycin Impurity 5
  • CAT. No.D690029
  • CAS. No.NA
  • Mol. F.C75H105N17O27
  • Mol. W.1676.73 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity 6
Daptomycin Impurity 6
  • CAT. No.D690030
  • CAS. No.NA
  • Mol. F.C72H101N17O27
  • Mol. W.1636.67 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity 7
Daptomycin Impurity 7
  • CAT. No.D690031
  • CAS. No.NA
  • Mol. F.C72H101N17O27
  • Mol. W.1636.67 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity 8
Daptomycin Impurity 8
  • CAT. No.D690032
  • CAS. No.NA
  • Mol. F.C75H103N17O26
  • Mol. W.1658.72 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity 10
Daptomycin Impurity 10
  • CAT. No.D690034
  • CAS. No.NA
  • Mol. F.C73H103N17O27
  • Mol. W.1650.70 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin 7-asp open Acid
Daptomycin 7-asp open Acid
  • CAT. No.D690035
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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Daptomycin open lactone benzazepinedione analog
Daptomycin open lactone benzazepinedione analog
  • CAT. No.D690036
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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Daptomycin quinlinoyl analog
Daptomycin quinlinoyl analog
  • CAT. No.D690037
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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Daptomycin L-kynureninyl analog
Daptomycin L-kynureninyl analog
  • CAT. No.D690038
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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Daptomycin decaenoyl analog
Daptomycin decaenoyl analog
  • CAT. No.D690039
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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N-Formyl daptomycin
N-Formyl daptomycin
  • CAT. No.D690040
  • CAS. No.NA
  • Mol. F.C73H101N17O27
  • Mol. W.1648.68 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin 4-isocrotonyl open lactone
Daptomycin 4-isocrotonyl open lactone
  • CAT. No.D690041
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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Daptomycin isodecanoyl analog
Daptomycin isodecanoyl analog
  • CAT. No.D690042
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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Daptomycin 8-glycine
Daptomycin 8-glycine
  • CAT. No.D690043
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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Daptomycin 8-D-serine
Daptomycin 8-D-serine
  • CAT. No.D690044
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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Daptomycin 6-L-lysine
Daptomycin 6-L-lysine
  • CAT. No.D690045
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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Daptomycin 11-glycine
Daptomycin 11-glycine
  • CAT. No.D690046
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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7-Asp anhydrodaptomycin
7-Asp anhydrodaptomycin
  • CAT. No.D690047
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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Daptomycin 8-methyldecanoyl analog
Daptomycin 8-methyldecanoyl analog
  • CAT. No.D690048
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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Daptomycin 2-D-Alanine Analog
Daptomycin 2-D-Alanine Analog
  • CAT. No.D690049
  • CAS. No.2440130-58-3
  • Mol. F.C71H100N16O25
  • Mol. W.1577.65 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity 3
Daptomycin Impurity 3
  • CAT. No.D690050
  • CAS. No.NA
  • Mol. F.C71H99N17O26
  • Mol. W.1606.64 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity 12
Daptomycin Impurity 12
  • CAT. No.D690051
  • CAS. No.NA
  • Mol. F.C73H103N17O26
  • Mol. W.1634.70 g/mol
  • Stock Status:Custom Synthesis
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Daptomycin Impurity 11
Daptomycin Impurity 11
  • CAT. No.D690052
  • CAS. No.NA
  • Mol. F.C72H99N17O26
  • Mol. W.1618.65 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Daptomycin D5 Trifluoroacetic Acid
Daptomycin D5 Trifluoroacetic Acid
  • CAT. No.D690003
  • CAS. No.1356579-56-0
  • Mol. F.C72H96D5N17O26.C2HFO2
  • Mol. W.1967.77 g/mol
  • Stock Status:Instock
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