Dabrafenib Related Compounds & Impurities

Dabrafenib is a selective ATP-competitive BRAF kinase inhibitor used in combination with the MEK inhibitor trametinib for BRAF V600-mutant melanoma, NSCLC and thyroid cancer.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Dabrafenib reference standards, pharmacopeial and non-pharmacopeial Dabrafenib impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Dabrafenib-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Dabrafenib
Dabrafenib
  • CAT. No.D1040000
  • CAS. No.1195765-45-7
  • Mol. F.C23H20F3N5O2S2
  • Mol. W.519.56 g/mol
  • Stock Status:Instock
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Dabrafenib Mesylate
Dabrafenib Mesylate
  • CAT. No.D1040002
  • CAS. No.1195768-06-9
  • Mol. F.C24H24F3N5O5S3
  • Mol. W.615.67 g/mol
  • Stock Status:Instock
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Dabrafenib Impurity 10
Dabrafenib Impurity 10
  • CAT. No.D1040006
  • CAS. No.NA
  • Mol. F.C15H15FN2O2S
  • Mol. W.306.40 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib N-Oxide Impurity 2
Dabrafenib N-Oxide Impurity 2
  • CAT. No.D1040007
  • CAS. No.NA
  • Mol. F.C23H20F3N5O3S2
  • Mol. W.535.60 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 11
Dabrafenib Impurity 11
  • CAT. No.D1040008
  • CAS. No.NA
  • Mol. F.C22H20FN5O2S2
  • Mol. W.469.60 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Di-N-Oxide Impurity
Dabrafenib Di-N-Oxide Impurity
  • CAT. No.D1040009
  • CAS. No.NA
  • Mol. F.C23H20F3N5O4S2
  • Mol. W.551.60 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 12
Dabrafenib Impurity 12
  • CAT. No.D1040010
  • CAS. No.NA
  • Mol. F.C22H16F2N4O2S2
  • Mol. W.470.50 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 13
Dabrafenib Impurity 13
  • CAT. No.D1040011
  • CAS. No.NA
  • Mol. F.C23H19F2N5O2S2
  • Mol. W.499.60 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 14
Dabrafenib Impurity 14
  • CAT. No.D1040012
  • CAS. No.NA
  • Mol. F.C15H14F3N3O2S
  • Mol. W.357.40 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 15
Dabrafenib Impurity 15
  • CAT. No.D1040013
  • CAS. No.NA
  • Mol. F.C23H18F3N5O2S2
  • Mol. W.517.50 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 7
Dabrafenib Impurity 7
  • CAT. No.D1040014
  • CAS. No.1176126-31-0
  • Mol. F.C7H6ClFO3S
  • Mol. W.224.63 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 1
Dabrafenib Impurity 1
  • CAT. No.D1040015
  • CAS. No.2017554-98-0
  • Mol. F.C23H22F2N6O2S2
  • Mol. W.516.60 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 2
Dabrafenib Impurity 2
  • CAT. No.D1040016
  • CAS. No.NA
  • Mol. F.C24H23F2N5O3S2
  • Mol. W.531.60 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 3
Dabrafenib Impurity 3
  • CAT. No.D1040017
  • CAS. No.NA
  • Mol. F.C23H21F2N5O2S2
  • Mol. W.501.60 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 17
Dabrafenib Impurity 17
  • CAT. No.D1040018
  • CAS. No.NA
  • Mol. F.C23H19F3N4O3S2
  • Mol. W.520.50 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 18
Dabrafenib Impurity 18
  • CAT. No.D1040019
  • CAS. No.NA
  • Mol. F.C18H12F3N3O4S
  • Mol. W.423.40 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 19
Dabrafenib Impurity 19
  • CAT. No.D1040020
  • CAS. No.447460-43-7
  • Mol. F.C6H3F3O2S
  • Mol. W.196.10 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 20
Dabrafenib Impurity 20
  • CAT. No.D1040021
  • CAS. No.NA
  • Mol. F.C23H21F3N4O4S2
  • Mol. W.538.60 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 16
Dabrafenib Impurity 16
  • CAT. No.D1040022
  • CAS. No.1195768-19-4
  • Mol. F.C14H10F3NO4S
  • Mol. W.345.30 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Amine Impurity
Dabrafenib Amine Impurity
  • CAT. No.D1040023
  • CAS. No.1195769-01-7
  • Mol. F.C17H18FN5S
  • Mol. W.343.42 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 23
Dabrafenib Impurity 23
  • CAT. No.D1040024
  • CAS. No.NA
  • Mol. F.C24H13ClF5N3O5S2
  • Mol. W.617.95 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 24
Dabrafenib Impurity 24
  • CAT. No.D1040025
  • CAS. No.NA
  • Mol. F.C18H13F3N4O3S
  • Mol. W.422.38 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 25
Dabrafenib Impurity 25
  • CAT. No.D1040026
  • CAS. No.NA
  • Mol. F.C18H12ClF2N3O4S
  • Mol. W.439.82 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 26
Dabrafenib Impurity 26
  • CAT. No.D1040027
  • CAS. No.NA
  • Mol. F.C12H9ClFN3O
  • Mol. W.265.67 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib N-Oxide Impurity
Dabrafenib N-Oxide Impurity
  • CAT. No.D1040028
  • CAS. No.NA
  • Mol. F.C23H20F3N5O3S2
  • Mol. W.535.56 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Methoxy Impurity
Dabrafenib Methoxy Impurity
  • CAT. No.D1040029
  • CAS. No.1907654-22-1
  • Mol. F.C24H21F3N4O3S2
  • Mol. W.534.57 g/mol
  • Stock Status:Custom Synthesis
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2,2-Dimethylthiopropionamide
2,2-Dimethylthiopropionamide
  • CAT. No.D1040030
  • CAS. No.630-22-8
  • Mol. F.C5H11NS
  • Mol. W.117.21 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 28
Dabrafenib Impurity 28
  • CAT. No.D1040031
  • CAS. No.1195768-20-7
  • Mol. F.C18H11ClF3N3O3S
  • Mol. W.441.81 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 4
Dabrafenib Impurity 4
  • CAT. No.D1040032
  • CAS. No.NA
  • Mol. F.C23H18ClF3N4O2S2
  • Mol. W.538.99 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 5
Dabrafenib Impurity 5
  • CAT. No.D1040033
  • CAS. No.NA
  • Mol. F.C23H21F2N5O3S2
  • Mol. W.517.57 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 6
Dabrafenib Impurity 6
  • CAT. No.D1040034
  • CAS. No.1195768-23-0
  • Mol. F.C23H18ClF3N4O2S2
  • Mol. W.538.99 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Diamine Sulfonamide Impurity
Dabrafenib Diamine Sulfonamide Impurity
  • CAT. No.D1040035
  • CAS. No.NA
  • Mol. F.C23H22F2N6O2S2
  • Mol. W.516.59 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Mesylate Form-I
Dabrafenib Mesylate Form-I
  • CAT. No.D1040036
  • CAS. No.1195768-06-9
  • Mol. F.C24H24F3N5O5S3
  • Mol. W.615.67 g/mol
  • Stock Status:Please Enquire
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Dabrafenib Impurity 8
Dabrafenib Impurity 8
  • CAT. No.D1040037
  • CAS. No.1195768-10-5
  • Mol. F.C23H19ClF2N4O2S2
  • Mol. W.521.00 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 9
Dabrafenib Impurity 9
  • CAT. No.D1040038
  • CAS. No.NA
  • Mol. F.C15H12F3NO4S
  • Mol. W.359.32 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 22
Dabrafenib Impurity 22
  • CAT. No.D1040039
  • CAS. No.NA
  • Mol. F.C20H12F5NO6S2
  • Mol. W.521.43 g/mol
  • Stock Status:Custom Synthesis
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Dabrafenib Impurity 21
Dabrafenib Impurity 21
  • CAT. No.D1040040
  • CAS. No.923880-43-7
  • Mol. F.C14H11F2NO4S
  • Mol. W.327.30 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

Hydroxy Dabrafenib
Hydroxy Dabrafenib
  • CAT. No.D1040003
  • CAS. No.1195767-77-1
  • Mol. F.C23H20F3N5O3S2
  • Mol. W.535.56 g/mol
  • Stock Status:Custom Synthesis
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Desmethyl-Dabrafenib
Desmethyl-Dabrafenib
  • CAT. No.D1040004
  • CAS. No.1195765-47-9
  • Mol. F.C22H18F3N5O2S2
  • Mol. W.505.54 g/mol
  • Stock Status:Custom Synthesis
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Carboxy Dabrafenib
Carboxy Dabrafenib
  • CAT. No.D1040005
  • CAS. No.1195873-54-1
  • Mol. F.C23H18F3N5O4S2
  • Mol. W.549.55 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Dabrafenib-D9
Dabrafenib-D9
  • CAT. No.D1040001
  • CAS. No.1423119-98-5
  • Mol. F.C23H11D9F3N5O2S2
  • Mol. W.528.62 g/mol
  • Stock Status:Custom Synthesis
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