Blog Date 29 March, 2023

Rosuvastatin Acid Action on Cholesterol

Rosuvastatin Acid Action on Cholesterol

A class of drugs that helps in lowering the cholesterol levels in the blood are known as Statins. Rosuvastatin is a synthetic, enantiomerically pure antilipemic agent. It is used to lower total cholesterol, low-density lipoprotein-cholesterol (LDL-C), apolipoprotein B (apoB), non-high density lipoprotein-cholesterol (non-HDL-C), and trigleride (TG) plasma concentrations while increasing HDL-C concentrations. By decreasing LDL-C and TG and increasing HDL-C, rosuvastatin reduces the risk of cardiovascular morbidity and mortality.

Rosuvastatin is a 3-hydroxy-3-methylglutaryl–coenzyme A reductase inhibitor (statin) that has been developed for the treatment of dyslipidemia. Use of Statins to Lower LDL levels helps in preventing heart attack, stroke and other related cardiovascular diseases.

Types of Cholesterol:

  1. HDL Cholesterol
  2. LDL Cholesterol

The clinical dosage range for Atorvastatin is 10-40 mg/day results in 45.8% to 54.6% reduction in LDL Cholesterol level.

Rosuvastatin Acid

Cas No: 287714-41-4

Rosuvastatin is also a unique member of the class of statins due to its high hydrophilicity which increases hepatic uptake at the site of action, low bioavailability, and minimal metabolism via the Cytochrome P450 system.

 Isotopic form of Rosuvastatin - Rosuvastatin D6 Sodium

Product ID: R060034


Rosuvastatin-d6 is intended for use as an internal standard for the quantification of rosuvastatin by GC- or LC-MS.

Rosuvastatin is an inhibitor of HMG-CoA reductase (IC50 = 5 nM).

It inhibits cholesterol synthesis in isolated rat hepatocytes with an IC50 value of 0.16 nM.

Simson Pharma is a research-based organization that offers high purity, high-quality reference standards of Rosuvastatin acid, its known and unknown impurities and related substances at very competitive prices.

A total number of 107 impurities of Rosuvastatin acid are available at Simson Pharma which includes all the known, unknown, in house impurities and Deuterium labeled compounds as well.

Follow the link below for more detail:

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