Nitrosamine Compounds About Us

Nitrosamine are organic compounds with the chemical structure R2N−N=O, where R is usually an alkyl group  They feature a nitroso group (NO+) bonded to a deprotonated amine. Most nitrosamines are carcinogenic in nonhuman animals.

Formation of nitrosamines is carried out through a simple reaction in the presence of secondary, tertiary, or quaternary amines with a nitrating agent under acidic reaction conditions.

Simson is specialized in delivering nitroso amine impurities with Certificate of analysis along with characterization and purity. We are equipped with ultra-high performance LC-MS and Triple triple quadrupole MS Mass Spectrometers for accurate determination of purity.

SimSon Pharma provides synthetic and analytical services for custom synthesis of Drug impurities,peptides,metabolites and nitrososmine impurities from miligram to multi gram level.

 

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List of Nitrosamine Compounds | Nitrosamine Impurities

N-Nitroso Aceclofenac
Methyl {2-[(2,6-dichlorophenyl) (nitroso) amino]phenyl}acetate
Ethyl{2-[(2,6-dichlorophenyl)(nitroso)amino]phenyl}acetate
({[({2-[(2,6-dichlorophenyl)(nitroso)amino]phenyl}acetyl)oxy]acetyl}oxy)acetic acid
{[({[({2-[(2,6-dichlorophenyl)(nitroso)amino]phenyl}acetyl)oxy]acetyl}oxy)acetyl]oxy}acetic acid
2-[(2,6-Dichlorophenyl)(nitroso)amino]benzeneacetic acid 2-ethoxy-2-oxoethyl ester
benzyl[[[2-[(2,6-dichlorophenyl)(nitroso)amino]phenyl]acetyl]oxy]acetate
Di-Nitroso of Aciclovir Impurity K
Mono-Nitroso of Aciclovir Impurity K
N-Nitroso Albendazole
N-Nitroso Desethyl Amiodarone
N-Nitroso Amlodipine
Nitroso Phthaloyl Amlodipine
N-Nitroso Levamlodipin
N-Nitroso Apremilast
(S)-N-(2-(1-(3-ethoxy-4-methoxy-5-nitrosophenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
N-(1-nitrosopiperidin-3-yl)acetamide
Alogliptin Nitroso Impurity 1
N-Nitroso Atenolol
N-Nitroso Atenolol-D7
N- Nitroso Atenolol Impurity G
N- Nitroso Atenolol Impurity H
N- Nitroso Atenolol Impurity I
N-Nitroso Afatinib
N-Nitroso Atorvastatin Impurity
N-(2-Hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)-N-nitrosoformamide
N-Nitroso Desformyl Arformoterol
N-Nitroso Desmethyl Arformoterol
N-Nitroso n-Acetyl Arformoterol
N-Nitroso Azithromycin EP Impurity A
N-Nitroso of Azithromycin Impurity I
N-Nitroso Azithromycin EP Impurity M
2-(4-nitrosopiperazin-1-yl)ethanol
N-Nitroso Aripiprazole
Aripiprazole Nitroso Impurity 1
N-Nitroso Aripiprazole Bromobutoxyquinoline Impurity
N-Nitroso Aripiprazole EP Impurity E
N-Nitroso Aripiprazole EP Impurity F
N-Nitroso Alprazolam USP Related Compound A
Acalabrutinib Nitroso Impurity 1
N-Nitroso Desmethyl Azelastine
Alectinib Nitroso Impurity 1
N-Nitroso Acetazolamide
N-Nitroso Apalutamide Amine Impurity
1-Nitroso-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
N-Nitroso Azelnidipine
Abemaciclib Nitroso Metabolites M2
Abemaciclib Nitroso Impurity 2
Abemaciclib Nitroso Impurity 3
Abemaciclib Nitroso Impurity 1
Amodiaquine Nitroso Impurity 1
N-Nitroso Ambroxol
4-amino-5-(ethylsulfonyl)-2-methoxy-N-[(1-nitrosopyrrolidin-2-yl)methyl]benzamide
N-Nitroso Acetylcysteine
N-Nitroso-Atomoxetine
N-Nitroso-Atomoxetine Hydrochloride
Abacavir Nitroso Impurity 2
Abacavir Nitroso Impurity 3
Abacavir Dinitroso Impurity
Abacavir Nitroso Impurity
Trans-2-Nitroso-5-nitro-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7] oxepino [4,5-c]-pyrrole
Trans-2-Nitroso-5-amino-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]-pyrrole
Trans-2-Nitroso-5-chloro-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]-pyrrole
Nitroso-2-(7-methoxy-1-naphthyl)-N-[2-(7-methoxy-1-naphthyl)ethyl]ethylamine
7-nitroso-7H-Purine-6-thiol
N-Nitroso Azilsartan
N-Nitroso Abiraterone Acetate Nitrite
N-Nitroso Anagrelide
Ethyl N-(2,3-dichloro-6-nitrobenzyl)-N- nitrosoglycinate hydrochloride
N-Nitroso Anagrelide USP Related Compound A
N-Nitroso Atropine EP Impurity B
Aprepitant Nitroso Impurity 1
N-Nitroso Axitinib
Axitinib Nitroso Impurity 2
Axitinib Nitroso Impurity 3
Axitinib Nitroso Impurity 4
Argatroban Nitroso Impurity
N-Nitroso-Acebutolol
N-Nitroso-Acebutolol-D7
Nitroso Adenine
N-Nitroso Acarbose
Apixaban Nitroso Impurity 1
Apixaban N-Nitroso amino pentanoic acid Impurity
Apixaban N-nitroso amino phenyl Impurity
1-(4-methoxyphenyl)-4-(2-(nitroso(4-(2-oxopiperidin-1-yl)phenyl)amino)ethyl)-1H-pyrazole-3,5-dicarboxamide
N-Dinitroso Almotriptan
N-Nitroso Desmethyl Almotriptan impurity
N-Nitroso Bisoprolol
N-Nitroso Bupropion
Nitroso Bendroflumethiazide
Baricitinib Nitroso Impurity
N-Nitroso Betahistine
Bosutinib Nitroso Impurity
7-(3-Chloropropoxy)-4-((2,4-dichloro-5-methoxyphenyl)nitrosoamino)-6-methoxyquinoline-3-carbonitrile
N-Nitroso Buprenorphine EP Impurity B
N-Nitroso Bicalutamide
N-Nitroso desethyl Blonanserin
N-(3,5-dibromo-2-nitrosobenzyl)-N-methylcyclohexanamine
N-Nitroso Benazepril
Buspirone Nitroso Impurity 1
N-Nitrosobutyl Bumetanide Impurity
Brimonidine Nitroso impurity 1
Brimonidine Nitroso impurity 2
Brimonidine Nitroso Impurity
Brinzolamide N-Nitroso
N-Nitroso-Desmethyl-Brinzolamide
N-Nitroso Benzocaine Impurity 1
Benzonatate Nitroso Impurity
Desbutyl Bupivacaine Nitroso Impurity
N-nitroso-betaxolol
N-Nitroso Bromocriptine
Brexpiprazole Nitroso impurity
Brexpiprazole Nitroso Impurity 1
Bilastine Nitroso Impurity 1
Bilastine-N-Nitrosoamine Impurity-1
Bilastine Nitroso Impurity 2
Nitroso-4-Hydroxy Carbazole Carvedilol
Nitroso-Epoxy Propoxy Carbazole Carvedilol
Nitroso Carvedilol
Carvedilol Nitroso Impurity 2
Carvedilol Nitroso Impurity 1
DiNitroso-Carvedilol
N-Nitroso Carvedilol Carbazole Impurity
1-((2-(2-methoxyphenoxy)ethyl)amino)-3-((9-nitroso-9H-carbazol-4- yl)oxy)propan-2-yl dihydrogen phosphate
1-((9H-carbazol-4-yl)oxy)-3-((2-(2- methoxyphenoxy)ethyl)(nitroso)amino)propan-2-yl dihydrogen phosphate
1-((9H-carbazol-4-yl)oxy)-3-(nitrosoamino)propan-2-yl dihydrogen phosphate
1-((9-nitroso-9H-carbazol-4-yl)oxy)-3-(nitrosoamino)propan-2-yl dihydrogen
Celecoxib Nitroso Impurity 4
Celecoxib Nitroso Impurity 2
N,N-Dinitroso-Ethylene Diaminodiacetic Acid
N-Nitroso Ciprofloxacin
Ciprofloxacin Nitroso Impurity C
N-Nitroso Citalopram
Clopidogrel Nitroso Impurity
Methyl2-(2-chlorophenyl)-2-(nitroso(2-(thiophen-2-yl)ethyl)amino)acetate
N-Nitroso Hydroxyzine EP Impurity A
4-(diphenylmethyl)-1-nitroso piperidine
N-Nitroso Cyclophosphamide
Cyclophosphamide Nitroso Impurity 1
Cyclophosphamide Nitroso Impurity 2
Cyclophosphamide Nitroso Impurity 3
N-Nitroso Desmethyl Cyclobenzaprine
Di-Nitroso Clonidine
N-Nitroso Clonidine
N-(2,6-Dichlorophenyl)-4,5-dihydro-1-nitroso-1H-imidazol-2-amine
Diethylamine Dinitroso Impurity
N-Nitroso Cilostazol
Caspofungin Nitroso Impurity
N-Nitroso Cabergoline Impurity 1
N-Nitroso Cabergoline Impurity 2
N-Nitroso-N-Methyl-O-Methyl-Hydroxylamine
Candesartan Nitroso Impurity
N-Nitroso Candesartan Cilexetil Impurity
N-Nitroso Candesartan
Methyl-2-(((2`-cyano[1,1`-biphenyl]-4-yl)methyl)(nitroso)amino)-3-nitrobenzoate
Methyl3-amino-2-(((2`-cyano-[1,1`-biphenyl]-4-yl)methyl)(nitroso)amino)benzoate
Carbinoxamine Nitroso Impurity 1
N-Nitroso Celiprolol
Clevidipine Nitroso Impurity
N-Nitroso Didecylamine
N-Nitroso Decyl Aminoquat
Nitroso Dexchlorpheniramine Maleate
N-Nitroso Desmethyl Chlorpheniramine
N-Nitroso Cimetidine
Cimetidine Nitroso Impurity 4
4-Amino-1,3-dimethyl-2,6-dioxy-5-nitrosopyrimidine
N-Nitroso-Cyclamate
N-Nitroso Cinacalcet
N-Nitroso N-Desmethyl Clindamycin
N-Nitroso-N-Desmethyl-Clarithromycin
N-Nitroso Clozapine
N-Nitroso desmethyl Clozapine impurity
8-Chloro-5-nitroso-5H-dibenzo[b,e][1,4]diazepin-1(10H)-one
2-((4-chloro-2-nitrophenyl)(nitroso)amino)benzoic acid
2-((2-amino-4-chlorophenyl)(nitroso)amino)benzoic acid
Chloroquine Nitroso Impurity
N-nitroso Carbidopa
2-chloro-5-(1-hydroxy-2-nitroso-3-oxoisoindolin-1-yl)benzenesulfonamide
N-Nitrosochlordiazepoxide
N-nitrosodihydrodibenzazepine
N-Nitroso Clomipramine EP Impurity F
N-Nitroso Desmethyl Clomipramine
N-Nitroso Chlorpromazine Impurity
N-Nitrosodiclofenac
2-methoxy-2-oxoethyl2-(2-((2,6-dichlorophenyl)(nitroso)amino)phenyl)acetate
Dobutamine N-Nitroso impurity
N-Nitroso Donepezil
N-Nitroso N-Desmethyl Doxepin Impurity
N-Nitroso Desmethyl Cis-Doxepin
Duloxetine Nitroso Impurity 1
Duloxetine Nitroso Impurity 2
N-Nitroso Duloxetine
Nitroso Doluxetin EP Impurity C
Nitroso Doluxetin EP Impurity E
Nitroso Doluxetin EP Impurity F
Racemic Duloxetine Nitroso-D3
N-Nitroso Duloxetine-D7
5-chloro-1-(1-nitrosopiperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
N-Nitroso Domperidone
N-Nitroso Domperidone Impurity 4
1-(3-(4-(6-chloro-1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)piperidin-1-yl)propyl)-3-nitroso-1H-benzo[d]imidazol-2(3H)-one
N-Nitrosomethylphenidate
N-Nitroso Desloratadine
Darolutamide Nitroso Impurity
N-Nitroso Diazepam EP Impurity D
Dabigatran Nitroso Impurity 15
N-nitroso-4(methylamino)3-nitrobenzoic acid
Dabigatran Nitroso Impurity 3
Dabigatran Nitroso Impurity 4
N-(4-cyanophenyl)nitroso glycine
Nitroso DEM-1
N-Nitroso dabigatran Impurity
Dabigatran Nitroso Impurity 8
N-Nitroso-N-Desmethyl Doxycycline
N-Nitroso Methacycline
N-Nitroso2-acetyl-2-decarbamoyldoxycycline
Dorzolamide nitroso Impurity
Dorzolamide Nitroso Impurity
Mefenamic Acid Nitroso Impurity 1
N-Nitroso Dimenhydrinate EP Impurity F
N-desmethyl N-nitroso Diltiazem
N-Nitroso Diltiazem EP Impurity G
N-nitroso-Chloroethyl methylamine hydrochloride
N-Nitroso N-Desmethyl Deferiprone
N-Nitroso-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline
N-nitroso-3-methoxymorphinan
N-Nitroso Desmethyl Dextromethorphan
N-(4-(2-(Methyl(nitroso)amino)ethoxy)phenyl)methanesulfonamide
N-Nitroso Dofetilide Impurity 1
N-Nitroso Dolutegravir
Dasatinib Nitroso Impurity
Diethyl Nitrosoamino Malonate
N-Nitroso Enalapril
Nitroso Enalapril Impurity A
Nitroso Enalapril Impurity C
Nitroso Enalapril Impurity G
Nitroso Enalapril Impurity H
5-methoxy-1-nitroso-1H-benzo[d]imidazole-2-thiol
5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)thio)-1-nitroso-1H-benzo[d]imidazole
N-Nitroso Desmethoxy Esomeprazole
N-Nitroso Esomeprazole
N-nitroso-Etodolac Methyl Ester
N-nitroso Etodolac
N-nitroso-2-ethyl phenylhydrazine
N-nitroso Tryptophol
N-Nitroso Escitalopram Impurity
Nitroso Impurity of R-Escitalopram
Nitroso-Escitalopram Impurity A
Nitroso-Escitalopram Impurity B
N-Nitroso, N-Demethyl Erythromycin A
N-Nitroso-Desmethyl Erythromycin Ethyl Succinate
Mononitroso Ethambutol
Dinitroso Ethambutol
N-Nitroso Ezetimib
Ezetimibe Nitroso Impurity 4
Elagolix Nitroso Impurity
Erdafitinib Nitroso Impurity
Ethyl N-Nitroso-N-(1-phenylethyl)glycinate
Erlotinib Nitroso Impurity
N-Nitroso Desmethyl Eletriptan
N-Nitroso Eletriptan
N-Nitroso Enzalutamide Impurity
Nitroso Eptifibatide Impurity
Nitroso-Eltrombopag
Eltrombopag Nitroso Impurity 1
N-Nitroso Edoxaban Impurity 1
N-Nitroso Edoxaban Impurity 2
N-Nitroso Edoxaban Impurity 4
N-Nitroso Edoxaban Impurity 5
N-Nitroso Edoxaban Impurity 3
N-Nitroso Eliglustat
Etravirine Nitroso Impurity
N-Nitroso Ertapenem
N-Nitroso Ephedrine