Brimonidine Related Compounds & Impurities

Brimonidine is a selective alpha-2 adrenergic agonist used as an ophthalmic solution for glaucoma and ocular hypertension, and at lower concentration for facial rosacea erythema.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Brimonidine reference standards, pharmacopeial and non-pharmacopeial Brimonidine impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Brimonidine-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Brimonidine Tartrate
Brimonidine Tartrate
  • CAT. No.B330000
  • CAS. No.70359-46-5
  • Mol. F.C11H10BrN5.C4H6O6
  • Mol. W.442.22 g/mol
  • Stock Status:Instock
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Brimonidine Impurity I
Brimonidine Impurity I
  • CAT. No.B330001
  • CAS. No.134892-46-9
  • Mol. F.C9H4BrN3S
  • Mol. W.266.12 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine EP Impurity B
Brimonidine EP Impurity B
  • CAT. No.B330002
  • CAS. No.50358-63-9
  • Mol. F.C8H6BrN3
  • Mol. W.224.06 g/mol
  • Stock Status:Instock
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Brimonidine Impurity E Hydrochloride
Brimonidine Impurity E Hydrochloride
  • CAT. No.B330004
  • CAS. No.NA
  • Mol. F.C9H9BrClN5
  • Mol. W.302.56 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine EP Impurity E
Brimonidine EP Impurity E
  • CAT. No.B330004A
  • CAS. No.168329-48-4
  • Mol. F.C9H8BrN5
  • Mol. W.266.10 g/mol
  • Stock Status:Instock
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Brimonidine EP Impurity C
Brimonidine EP Impurity C
  • CAT. No.B330005
  • CAS. No.6298-37-9
  • Mol. F.C8H7N3
  • Mol. W.145.17 g/mol
  • Stock Status:Instock
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Brimonidine EP Impurity D
Brimonidine EP Impurity D
  • CAT. No.B330006
  • CAS. No.842138-74-3
  • Mol. F.C9H7BrN4S
  • Mol. W.283.15 g/mol
  • Stock Status:Instock
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Brimonidine EP Impurity F
Brimonidine EP Impurity F
  • CAT. No.B330007
  • CAS. No.151110-15-5
  • Mol. F.C11H8BrN5
  • Mol. W.290.12 g/mol
  • Stock Status:Instock
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Brimonidine EP Impurity G Hydrochloride
Brimonidine EP Impurity G Hydrochloride
  • CAT. No.B330008
  • CAS. No.NA
  • Mol. F.C11H13BrClN5O
  • Mol. W.346.62 g/mol
  • Stock Status:Instock
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Brimonidine EP Impurity G Trifluoroaceticacid
Brimonidine EP Impurity G Trifluoroaceticacid
  • CAT. No.B330008A
  • CAS. No.1391054-10-6
  • Mol. F.C13H13BrF3N5O3
  • Mol. W.424.17 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine EP Impurity G
Brimonidine EP Impurity G
  • CAT. No.B330008B
  • CAS. No.1216379-05-3
  • Mol. F.C11H12BrN5O
  • Mol. W.310.15 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine-2,3-dione
Brimonidine-2,3-dione
  • CAT. No.B330009
  • CAS. No.182627-95-8
  • Mol. F.C11H10BrN5O2
  • Mol. W.324.13 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine-2,3-Dione Hydrochloride
Brimonidine-2,3-Dione Hydrochloride
  • CAT. No.B330009A
  • CAS. No.NA
  • Mol. F.C11H11BrClN5O2
  • Mol. W.360.59 g/mol
  • Stock Status:Instock
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Brimonidine EP Impurity A p-toluenesulfonate
Brimonidine EP Impurity A p-toluenesulfonate
  • CAT. No.B330010
  • CAS. No.NA
  • Mol. F.C18H19N5O3S
  • Mol. W.385.44 g/mol
  • Stock Status:Instock
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Brimonidine EP Impurity A
Brimonidine EP Impurity A
  • CAT. No.B330010A
  • CAS. No.91147-43-2
  • Mol. F.C11H11N5
  • Mol. W.213.23 g/mol
  • Stock Status:Instock
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Brimonidine EP Impurity H
Brimonidine EP Impurity H
  • CAT. No.B330011
  • CAS. No.91147-46-5
  • Mol. F.C11H10ClN5
  • Mol. W.247.68 g/mol
  • Stock Status:Instock
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Brimonidine Related Impurity 4
Brimonidine Related Impurity 4
  • CAT. No.B330012
  • CAS. No.182628-02-0
  • Mol. F.C9H5BrN4
  • Mol. W.249.07 g/mol
  • Stock Status:Instock
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Brimonidine Carbamothioate Impurity
Brimonidine Carbamothioate Impurity
  • CAT. No.B330013
  • CAS. No.842138-75-4
  • Mol. F.C11H10BrN3OS
  • Mol. W.312.19 g/mol
  • Stock Status:Instock
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Brimonidine EP Impurity A
Brimonidine EP Impurity A
  • CAT. No.B330014
  • CAS. No.91147-43-2
  • Mol. F.C11H11N5
  • Mol. W.213.24 g/mol
  • Stock Status:Instock
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Brimonidine Dimer
Brimonidine Dimer
  • CAT. No.B330016
  • CAS. No.NA
  • Mol. F.C23H20Br2N10
  • Mol. W.596.28 g/mol
  • Stock Status:Instock
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5-bromo-6-(imidazolin-4-on-2-yl)aminoquinoxaline
5-bromo-6-(imidazolin-4-on-2-yl)aminoquinoxaline
  • CAT. No.B330017
  • CAS. No.NA
  • Mol. F.C11H8BrN5O
  • Mol. W.306.12 g/mol
  • Stock Status:Custom Synthesis
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5-bromo-6-N-(2-imidazol-4,5-dionyl)aminoquinxoaline
5-bromo-6-N-(2-imidazol-4,5-dionyl)aminoquinxoaline
  • CAT. No.B330018
  • CAS. No.NA
  • Mol. F.C11H6BrN5O2
  • Mol. W.320.10 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Acrylate
Brimonidine Acrylate
  • CAT. No.B330019
  • CAS. No.NA
  • Mol. F.C14H14BrN5O2
  • Mol. W.364.20 g/mol
  • Stock Status:Instock
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6-(2-Imidazoline-2-ylamino)quinoxaline
6-(2-Imidazoline-2-ylamino)quinoxaline
  • CAT. No.B330020
  • CAS. No.NA
  • Mol. F.C11H11N5
  • Mol. W.213.24 g/mol
  • Stock Status:Instock
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Brimonidine Propanoic Acid Analog
Brimonidine Propanoic Acid Analog
  • CAT. No.B330021
  • CAS. No.NA
  • Mol. F.C14H14BrN5O2
  • Mol. W.364.20 g/mol
  • Stock Status:Custom Synthesis
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5-bromo-6-[(imidazolin-2-ylamino)]-quinoxalin-2(1H)-one
5-bromo-6-[(imidazolin-2-ylamino)]-quinoxalin-2(1H)-one
  • CAT. No.B330022
  • CAS. No.NA
  • Mol. F.C11H12BrN5O
  • Mol. W.310.15 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Open Ring Impurity
Brimonidine Open Ring Impurity
  • CAT. No.B330023
  • CAS. No.134892-47-0
  • Mol. F.C11H12BrN5S
  • Mol. W.326.22 g/mol
  • Stock Status:Custom Synthesis
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1-Fumaric Acid Brimonidine
1-Fumaric Acid Brimonidine
  • CAT. No.B330024
  • CAS. No.NA
  • Mol. F.C15H12BrN5O3
  • Mol. W.390.19 g/mol
  • Stock Status:Instock
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BrimonidineUnknown Impurity I
BrimonidineUnknown Impurity I
  • CAT. No.B330025
  • CAS. No.NA
  • Mol. F.C15H14BrN5O3
  • Mol. W.392.21 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 9
Brimonidine Impurity 9
  • CAT. No.B330026
  • CAS. No.NA
  • Mol. F.C15H14BrN5O4
  • Mol. W.408.21 g/mol
  • Stock Status:Instock
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Brimonidine Nitroso impurity 1
Brimonidine Nitroso impurity 1
  • CAT. No.B330027
  • CAS. No.NA
  • Mol. F.C11H8BrN7O2
  • Mol. W.350.13 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Nitroso impurity 2
Brimonidine Nitroso impurity 2
  • CAT. No.B330028
  • CAS. No.NA
  • Mol. F.C11H9BrN6O
  • Mol. W.321.13 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Nitroso Impurity
Brimonidine Nitroso Impurity
  • CAT. No.B330029
  • CAS. No.NA
  • Mol. F.C11H9BrN6O
  • Mol. W.321.13 g/mol
  • Stock Status:Instock
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Acetyl Brimonidine
Acetyl Brimonidine
  • CAT. No.B330030
  • CAS. No.1158184-23-6
  • Mol. F.C13H12BrN5O
  • Mol. W.334.17 g/mol
  • Stock Status:Instock
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Brimonidine Impurity 13
Brimonidine Impurity 13
  • CAT. No.B330031
  • CAS. No.934548-66-0
  • Mol. F.C15H12BrN5O3
  • Mol. W.390.19 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 8
Brimonidine Impurity 8
  • CAT. No.B330032
  • CAS. No.185312-10-1
  • Mol. F.C11H9N5
  • Mol. W.211.22 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Tartrate EP Impurity G
Brimonidine Tartrate EP Impurity G
  • CAT. No.B330033
  • CAS. No.1216379-05-3
  • Mol. F.C11H12BrN5O
  • Mol. W.310.15 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 2
Brimonidine Impurity 2
  • CAT. No.B330034
  • CAS. No.NA
  • Mol. F.C22H18Br2N10
  • Mol. W.582.25 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Tartrate Impurity 3
Brimonidine Tartrate Impurity 3
  • CAT. No.B330035
  • CAS. No.1217439-06-9
  • Mol. F.C13H14N4
  • Mol. W.226.28 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 5
Brimonidine Impurity 5
  • CAT. No.B330036
  • CAS. No.2742962-04-3
  • Mol. F.C12H12BrN3OS
  • Mol. W.326.21 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Related Impurity 3
Brimonidine Related Impurity 3
  • CAT. No.B330038
  • CAS. No.135306-56-8
  • Mol. F.C9H5N3S
  • Mol. W.187.22 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine USP Related Compound E
Brimonidine USP Related Compound E
  • CAT. No.B330039
  • CAS. No.NA
  • Mol. F.C9H10BrCl2N5
  • Mol. W.339.02 g/mol
  • Stock Status:Custom Synthesis
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9,10-dihydro-8H-imidazo[2`,1`,2,3]imidazo[4,5-f]quinoxaline
9,10-dihydro-8H-imidazo[2`,1`,2,3]imidazo[4,5-f]quinoxaline
  • CAT. No.B330040
  • CAS. No.NA
  • Mol. F.C11H9N5
  • Mol. W.211.22 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 20
Brimonidine Impurity 20
  • CAT. No.B330041
  • CAS. No.NA
  • Mol. F.C11H12BrN5O
  • Mol. W.310.15 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 19
Brimonidine Impurity 19
  • CAT. No.B330042
  • CAS. No.NA
  • Mol. F.C16H17BrN6O
  • Mol. W.389.25 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 22
Brimonidine Impurity 22
  • CAT. No.B330043
  • CAS. No.NA
  • Mol. F.C15H12BrN5O3
  • Mol. W.390.19 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 23
Brimonidine Impurity 23
  • CAT. No.B330044
  • CAS. No.NA
  • Mol. F.C11H12BrN5O
  • Mol. W.310.15 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 20 Hydrochloride
Brimonidine Impurity 20 Hydrochloride
  • CAT. No.B330045
  • CAS. No.NA
  • Mol. F.C11H13BrClN5O
  • Mol. W.346.61 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 19 Hydrochloride
Brimonidine Impurity 19 Hydrochloride
  • CAT. No.B330046
  • CAS. No.NA
  • Mol. F.C16H18BrClN6O
  • Mol. W.425.71 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 25
Brimonidine Impurity 25
  • CAT. No.B330047
  • CAS. No.NA
  • Mol. F.C17H10BrN5O2
  • Mol. W.396.20 g/mol
  • Stock Status:Custom Synthesis
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(E)-3-(2-((5-bromoquinoxalin-6-yl)amino)-4,5-dihydro-1H-imidazol-1-yl)acrylicacid
(E)-3-(2-((5-bromoquinoxalin-6-yl)amino)-4,5-dihydro-1H-imidazol-1-yl)acrylicacid
  • CAT. No.B330048
  • CAS. No.NA
  • Mol. F.C14H12BrN5O2
  • Mol. W.362.18 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 27
Brimonidine Impurity 27
  • CAT. No.B330049
  • CAS. No.NA
  • Mol. F.C13H10BrN5O
  • Mol. W.332.20 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 10
Brimonidine Impurity 10
  • CAT. No.B330050
  • CAS. No.NA
  • Mol. F.C11H9N5
  • Mol. W.211.20 g/mol
  • Stock Status:Instock
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Brimonidine Impurity 28
Brimonidine Impurity 28
  • CAT. No.B330051
  • CAS. No.NA
  • Mol. F.C13H10BrN5O2
  • Mol. W.348.20 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 29
Brimonidine Impurity 29
  • CAT. No.B330052
  • CAS. No.NA
  • Mol. F.C15H12BrN5O3
  • Mol. W.390.20 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 30
Brimonidine Impurity 30
  • CAT. No.B330053
  • CAS. No.NA
  • Mol. F.C15H14BrN5O4
  • Mol. W.408.20 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Brimonidine EP Impurity F
N-Nitroso Brimonidine EP Impurity F
  • CAT. No.B330054
  • CAS. No.NA
  • Mol. F.C11H7BrN6O
  • Mol. W.319.10 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Nitroso Impurity 3
Brimonidine Nitroso Impurity 3
  • CAT. No.B330055
  • CAS. No.NA
  • Mol. F.C15H11BrN6O4
  • Mol. W.419.20 g/mol
  • Stock Status:Custom Synthesis
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5-bromo-N-(1,3-dinitrosoimidazolidin-2-ylidene)quinoxalin-6-amine
5-bromo-N-(1,3-dinitrosoimidazolidin-2-ylidene)quinoxalin-6-amine
  • CAT. No.B330056
  • CAS. No.NA
  • Mol. F.C11H8BrN7O2
  • Mol. W.350.13 g/mol
  • Stock Status:Instock
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Brimonidine Impurity 21
Brimonidine Impurity 21
  • CAT. No.B330057
  • CAS. No.NA
  • Mol. F.C15H16BrN5O5
  • Mol. W.426.20 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Tartrate Impurity
Brimonidine Tartrate Impurity
  • CAT. No.B330058
  • CAS. No.NA
  • Mol. F.C15H12BrN5O4
  • Mol. W.406.19 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 33
Brimonidine Impurity 33
  • CAT. No.B330059
  • CAS. No.NA
  • Mol. F.C16H13BrN4O3
  • Mol. W.389.20 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 4
Brimonidine Impurity 4
  • CAT. No.B330060
  • CAS. No.6639-91-4
  • Mol. F.C8H11N3
  • Mol. W.149.19 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 6
Brimonidine Impurity 6
  • CAT. No.B330061
  • CAS. No.1436426-14-0
  • Mol. F.C8H6BrN3
  • Mol. W.224.06 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 7
Brimonidine Impurity 7
  • CAT. No.B330062
  • CAS. No.1378255-24-3
  • Mol. F.C8H6BrN3
  • Mol. W.224.06 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 11
Brimonidine Impurity 11
  • CAT. No.B330063
  • CAS. No.NA
  • Mol. F.C8H5Br2N3
  • Mol. W.302.95 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 12
Brimonidine Impurity 12
  • CAT. No.B330064
  • CAS. No.NA
  • Mol. F.C8H5Br2N3
  • Mol. W.302.95 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 14
Brimonidine Impurity 14
  • CAT. No.B330065
  • CAS. No.NA
  • Mol. F.C15H12BrN5O3
  • Mol. W.390.20 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 15
Brimonidine Impurity 15
  • CAT. No.B330066
  • CAS. No.NA
  • Mol. F.C15H12BrN5O3
  • Mol. W.390.19 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Nitroso Impurity 4
Brimonidine Nitroso Impurity 4
  • CAT. No.B330067
  • CAS. No.NA
  • Mol. F.C11H9BrN6O
  • Mol. W.321.13 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 16
Brimonidine Impurity 16
  • CAT. No.B330068
  • CAS. No.NA
  • Mol. F.C14H12BrN5O
  • Mol. W.346.20 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 3
Brimonidine Impurity 3
  • CAT. No.B330069
  • CAS. No.NA
  • Mol. F.C12H11N5O3
  • Mol. W.273.25 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 17
Brimonidine Impurity 17
  • CAT. No.B330070
  • CAS. No.NA
  • Mol. F.C11H11Cl2N5O2
  • Mol. W.316.14 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 18
Brimonidine Impurity 18
  • CAT. No.B330071
  • CAS. No.NA
  • Mol. F.C11H10ClN5O2
  • Mol. W.279.68 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 24
Brimonidine Impurity 24
  • CAT. No.B330072
  • CAS. No.NA
  • Mol. F.C14H14BrN5O5
  • Mol. W.412.20 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 1
Brimonidine Impurity 1
  • CAT. No.B330073
  • CAS. No.NA
  • Mol. F.C11H9N5
  • Mol. W.211.22 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine Impurity 26
Brimonidine Impurity 26
  • CAT. No.B330074
  • CAS. No.NA
  • Mol. F.C11H10BrN5O2
  • Mol. W.324.13 g/mol
  • Stock Status:Custom Synthesis
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Brimonidine EP Impurity E
Brimonidine EP Impurity E
  • CAT. No.B360011
  • CAS. No.168329-48-4 (free base)
  • Mol. F.C9H8BrN5.C2HF3O2
  • Mol. W.380.12 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Brimonidine-D4
Brimonidine-D4
  • CAT. No.B330015
  • CAS. No.1184971-51-4
  • Mol. F.C11H6BrD4N5
  • Mol. W.296.16 g/mol
  • Stock Status:Custom Synthesis
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