Bosutinib Related Compounds & Impurities

Bosutinib is a second-generation BCR-ABL/Src kinase inhibitor used for chronic myeloid leukaemia resistant or intolerant to prior therapy.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Bosutinib reference standards, pharmacopeial and non-pharmacopeial Bosutinib impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Bosutinib-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Bosutinib
Bosutinib
  • CAT. No.B1020000
  • CAS. No.380843-75-4
  • Mol. F.C26H29Cl2N5O3
  • Mol. W.530.45 g/mol
  • Stock Status:Under Synthesis
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Bosutinib Impurity 8
Bosutinib Impurity 8
  • CAT. No.B1020002
  • CAS. No.846023-24-3
  • Mol. F.C10H8Cl2N2O2
  • Mol. W.259.10 g/mol
  • Stock Status:Instock
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Bosutinib Didesmethyl TriHydrochloride Impurity
Bosutinib Didesmethyl TriHydrochloride Impurity
  • CAT. No.B1020003
  • CAS. No.2468737-94-0(freebase)
  • Mol. F.C24H28Cl5N5O3
  • Mol. W.611.78 g/mol
  • Stock Status:Custom Synthesis
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2,4-Dichloro-5-methoxyaniline
2,4-Dichloro-5-methoxyaniline
  • CAT. No.B1020004
  • CAS. No.98446-49-2
  • Mol. F.C26H29Cl2N5O3
  • Mol. W.53.45 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib N-oxide
Bosutinib N-oxide
  • CAT. No.B1020011
  • CAS. No.2468737-96-2
  • Mol. F.C26H29Cl2N5O4
  • Mol. W.546.45 g/mol
  • Stock Status:Instock
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N-Desmethyl Bosutinib
N-Desmethyl Bosutinib
  • CAT. No.B1020012
  • CAS. No.380843-81-2
  • Mol. F.C25H27Cl2N5O3
  • Mol. W.516.42 g/mol
  • Stock Status:Instock
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Bosutinib 4-Chloro 7-Chloropropoxy Impurity
Bosutinib 4-Chloro 7-Chloropropoxy Impurity
  • CAT. No.B1020013
  • CAS. No.214470-68-5
  • Mol. F.C14H12Cl2N2O2
  • Mol. W.311.16 g/mol
  • Stock Status:Instock
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Bosutinib Impurity 8
Bosutinib Impurity 8
  • CAT. No.B1020014
  • CAS. No.380844-49-5
  • Mol. F.C21H18Cl3N3O3
  • Mol. W.466.74 g/mol
  • Stock Status:Instock
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Bosutinib 4-Hydroxy 7-Chloropropoxy Impurity
Bosutinib 4-Hydroxy 7-Chloropropoxy Impurity
  • CAT. No.B1020015
  • CAS. No.214470-66-3
  • Mol. F.C14H13ClN2O3
  • Mol. W.292.72 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Chloro Impurity
Bosutinib Chloro Impurity
  • CAT. No.B1020016
  • CAS. No.492444-39-0
  • Mol. F.C19H23ClN4O2
  • Mol. W.374.86 g/mol
  • Stock Status:Instock
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4-(2,4-Dichloro-5-methoxyphenylamino)-7-hydroxy-6-methoxyquinoline-3-carbonitrile
4-(2,4-Dichloro-5-methoxyphenylamino)-7-hydroxy-6-methoxyquinoline-3-carbonitrile
  • CAT. No.B1020017
  • CAS. No.1460227-29-5
  • Mol. F.C18H13Cl2N3O3
  • Mol. W.390.22 g/mol
  • Stock Status:Custom Synthesis
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4-(2,4-Dichloro-5-methoxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile
4-(2,4-Dichloro-5-methoxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile
  • CAT. No.B1020018
  • CAS. No.380843-12-9
  • Mol. F.C18H13Cl2N3O3
  • Mol. W.390.22 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib (Form-R)
Bosutinib (Form-R)
  • CAT. No.B1020019
  • CAS. No.NA
  • Mol. F.C26H29Cl2N5O3
  • Mol. W.53.45 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Desmethyl Impurity
Bosutinib Desmethyl Impurity
  • CAT. No.B1020020
  • CAS. No.2468737-92-8
  • Mol. F.C25H27Cl2N5O3
  • Mol. W.516.42 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib dimer impurity
Bosutinib dimer impurity
  • CAT. No.B1020021
  • CAS. No.NA
  • Mol. F.C47H46Cl4N8O6
  • Mol. W.960.73 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Regio isomer impurity
Bosutinib Regio isomer impurity
  • CAT. No.B1020022
  • CAS. No.1391063-17-4
  • Mol. F.C26H29CL2N5O3
  • Mol. W.530.45 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Monohydrate
Bosutinib Monohydrate
  • CAT. No.B1020023
  • CAS. No.918639-08-4
  • Mol. F.C26H29Cl2N5O3:H2O
  • Mol. W.548.46 g/mol
  • Stock Status:Instock
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Bosutinib Didesmethyl Impurity
Bosutinib Didesmethyl Impurity
  • CAT. No.B1020024
  • CAS. No.2468737-94-0
  • Mol. F.C24H25Cl2N5O3
  • Mol. W.502.40 g/mol
  • Stock Status:Under Synthesis
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7-(3-Chloropropoxy)-6-methoxy-4-(4-methyl piperazin-1-yl)quinolone-3-carbonitrile
7-(3-Chloropropoxy)-6-methoxy-4-(4-methyl piperazin-1-yl)quinolone-3-carbonitrile
  • CAT. No.B1020025
  • CAS. No.NA
  • Mol. F.C19H23ClN4O3
  • Mol. W.390.86 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Nitroso Impurity
Bosutinib Nitroso Impurity
  • CAT. No.B1020026
  • CAS. No.NA
  • Mol. F.C26H28Cl2N6O4
  • Mol. W.559.44 g/mol
  • Stock Status:Custom Synthesis
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7-(3-Chloropropoxy)-4-((2,4-dichloro-5-methoxyphenyl)nitrosoamino)-6-methoxyquinoline-3-carbonitrile
7-(3-Chloropropoxy)-4-((2,4-dichloro-5-methoxyphenyl)nitrosoamino)-6-methoxyquinoline-3-carbonitrile
  • CAT. No.B1020027
  • CAS. No.NA
  • Mol. F.C21H17Cl3N4O4
  • Mol. W.495.74 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Impurity II
Bosutinib Impurity II
  • CAT. No.B1020028
  • CAS. No.846023-56-1
  • Mol. F.C26H31Cl2N5O4
  • Mol. W.548.46 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Des NMP Impurity
Bosutinib Des NMP Impurity
  • CAT. No.B1020029
  • CAS. No.2095306-25-3
  • Mol. F.C21H19Cl2N3O3
  • Mol. W.432.30 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso N-Desmethyl Bosutinib
N-Nitroso N-Desmethyl Bosutinib
  • CAT. No.B1020031
  • CAS. No.NA
  • Mol. F.C25H26Cl2N6O4
  • Mol. W.545.42 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Bosutinib Impurity II
N-Nitroso Bosutinib Impurity II
  • CAT. No.B1020032
  • CAS. No.NA
  • Mol. F.C26H30Cl2N6O5
  • Mol. W.577.46 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Impurity 31
Bosutinib Impurity 31
  • CAT. No.B1020033
  • CAS. No.NA
  • Mol. F.C19H23ClN4O2
  • Mol. W.374.87 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Impurity 12
Bosutinib Impurity 12
  • CAT. No.B1020034
  • CAS. No.773084-45-0
  • Mol. F.C14H16BrNO4
  • Mol. W.342.19 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Dimer Impurity 2
Bosutinib Dimer Impurity 2
  • CAT. No.B1020035
  • CAS. No.2095306-26-4
  • Mol. F.C46H44Cl4N8O6
  • Mol. W.946.71 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Impurity 13
Bosutinib Impurity 13
  • CAT. No.B1020036
  • CAS. No.NA
  • Mol. F.C27H31Cl3N5O3
  • Mol. W.579.93 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Propoxy Dimer Impurity
Bosutinib Propoxy Dimer Impurity
  • CAT. No.B1020037
  • CAS. No.2095306-27-5
  • Mol. F.C39H30Cl4N6O6
  • Mol. W.820.51 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib N-Oxide Impurity 2
Bosutinib N-Oxide Impurity 2
  • CAT. No.B1020038
  • CAS. No.NA
  • Mol. F.C26H29Cl2N5O5
  • Mol. W.562.44 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib N-Oxide Impurity 3
Bosutinib N-Oxide Impurity 3
  • CAT. No.B1020039
  • CAS. No.NA
  • Mol. F.C26H29Cl2N5O4
  • Mol. W.546.45 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Impurity 2
Bosutinib Impurity 2
  • CAT. No.B1020040
  • CAS. No.7397-28-6
  • Mol. F.C8H6Cl3NO2
  • Mol. W.254.50 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Impurity 3
Bosutinib Impurity 3
  • CAT. No.B1020041
  • CAS. No.28443-52-9
  • Mol. F.C8H8ClNO2
  • Mol. W.185.61 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Impurity 4
Bosutinib Impurity 4
  • CAT. No.B1020042
  • CAS. No.1307530-78-4
  • Mol. F.C10H9ClN2O2
  • Mol. W.224.64 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Impurity 5
Bosutinib Impurity 5
  • CAT. No.B1020043
  • CAS. No.879644-03-8
  • Mol. F.C10H9ClN2O2
  • Mol. W.224.64 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Impurity 6
Bosutinib Impurity 6
  • CAT. No.B1020044
  • CAS. No.NA
  • Mol. F.C9H6Cl2N2O2
  • Mol. W.245.06 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Impurity 7
Bosutinib Impurity 7
  • CAT. No.B1020045
  • CAS. No.1821033-10-6
  • Mol. F.C10H8Cl2N2O2
  • Mol. W.259.09 g/mol
  • Stock Status:Custom Synthesis
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Bosutinib Impurity 1
Bosutinib Impurity 1
  • CAT. No.B1030011
  • CAS. No.NA
  • Mol. F.C27H31Cl3N5O3.Cl
  • Mol. W.615.38 g/mol
  • Stock Status:Custom Synthesis
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Brigatinib Impurity 4
Brigatinib Impurity 4
  • CAT. No.B1030012
  • CAS. No.28443-52-9
  • Mol. F.C8H8ClNO2
  • Mol. W.185.61 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Bosutinib D8
Bosutinib D8
  • CAT. No.B1020001
  • CAS. No.2733145-45-2
  • Mol. F.C26H21Cl2D8N5O3
  • Mol. W.538.50 g/mol
  • Stock Status:Instock
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Bosutinib D9
Bosutinib D9
  • CAT. No.B1020030
  • CAS. No.380843-75-4 unlabeled
  • Mol. F.C26H20D9Cl2N5O3
  • Mol. W.539.50 g/mol
  • Stock Status:Custom Synthesis
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