Bortezomib Related Compounds & Impurities

Bortezomib is a first-in-class reversible 26S proteasome inhibitor that disrupts protein homeostasis in malignant plasma cells, used for multiple myeloma and mantle cell lymphoma.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Bortezomib reference standards, pharmacopeial and non-pharmacopeial Bortezomib impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Bortezomib-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Bortezomib
Bortezomib
  • CAT. No.B260000
  • CAS. No.179324-69-7
  • Mol. F.C19H25BN4O4
  • Mol. W.384.24 g/mol
  • Stock Status:Instock
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Bortezomib Form II
Bortezomib Form II
  • CAT. No.B260000A
  • CAS. No.179324-69-7
  • Mol. F.C19H25BN4O4
  • Mol. W.384.24 g/mol
  • Stock Status:Instock
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Bortezomib R,R-Isomer Impurity
Bortezomib R,R-Isomer Impurity
  • CAT. No.B260001
  • CAS. No.1132709-15-9
  • Mol. F.C19H25BN4O4
  • Mol. W.384.24 g/mol
  • Stock Status:Instock
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Bortezomib Impurity G
Bortezomib Impurity G
  • CAT. No.B260002
  • CAS. No.289472-81-7
  • Mol. F.C19H24N4O3
  • Mol. W.356.42 g/mol
  • Stock Status:Limited Stock
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(S,R)-Bortezomib Hydroxyisopentyl Amide Analog
(S,R)-Bortezomib Hydroxyisopentyl Amide Analog
  • CAT. No.B260003
  • CAS. No.289472-78-2
  • Mol. F.C19H24N4O3
  • Mol. W.356.42 g/mol
  • Stock Status:Instock
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Bortezomib Impurity 36
Bortezomib Impurity 36
  • CAT. No.B260004
  • CAS. No.114457-94-2
  • Mol. F.C14H13N3O3
  • Mol. W.271.27 g/mol
  • Stock Status:Instock
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Bortezomib Impurity A
Bortezomib Impurity A
  • CAT. No.B260005
  • CAS. No.289472-80-6
  • Mol. F.C14H14N4O2
  • Mol. W.270.29 g/mol
  • Stock Status:Instock
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Bortezomib Pinanediol Ester
Bortezomib Pinanediol Ester
  • CAT. No.B260006
  • CAS. No.205393-22-2
  • Mol. F.C29H39BN4O4
  • Mol. W.518.46 g/mol
  • Stock Status:Instock
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Bortezomib Hydroxy Impurity (1R,2S)-Isomer
Bortezomib Hydroxy Impurity (1R,2S)-Isomer
  • CAT. No.B260007
  • CAS. No.NA
  • Mol. F.C19H24N4O3
  • Mol. W.356.43 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity (S,S-Isomer)
Bortezomib Impurity (S,S-Isomer)
  • CAT. No.B260008
  • CAS. No.1132709-14-8
  • Mol. F.C19H25BN4O4
  • Mol. W.384.24 g/mol
  • Stock Status:Instock
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Bortezomib (1S,2R)-Isomer
Bortezomib (1S,2R)-Isomer
  • CAT. No.B260009
  • CAS. No.1132709-16-0
  • Mol. F.C19H25BN4O4
  • Mol. W.384.24 g/mol
  • Stock Status:Instock
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Bortezomib Impurity C
Bortezomib Impurity C
  • CAT. No.B260011
  • CAS. No.862894-96-0
  • Mol. F.C19H22N4O3
  • Mol. W.354.40 g/mol
  • Stock Status:Instock
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Bortezomib Impurity F
Bortezomib Impurity F
  • CAT. No.B260012
  • CAS. No.73058-37-4
  • Mol. F.C15H15N3O3
  • Mol. W.285.31 g/mol
  • Stock Status:Instock
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Bortezomib Impurity H
Bortezomib Impurity H
  • CAT. No.B260013
  • CAS. No.1446194-56-4
  • Mol. F.C19H24N4O2
  • Mol. W.340.42 g/mol
  • Stock Status:Instock
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Bortezomib Impurity 42
Bortezomib Impurity 42
  • CAT. No.B260014
  • CAS. No.477254-69-6
  • Mol. F.C17H29BF3NO4
  • Mol. W.379.22 g/mol
  • Stock Status:Custom Synthesis
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(S)-3-Cyclopropyl-3-(3-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2`-fluoro-5`-methoxy-[1,1`-biphenyl]-4-yl)methoxy)phenyl)propanoic acid
(S)-3-Cyclopropyl-3-(3-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2`-fluoro-5`-methoxy-[1,1`-biphenyl]-4-yl)methoxy)phenyl)propanoic acid
  • CAT. No.B260016
  • CAS. No.1142214-62-7
  • Mol. F.C33H35FO4
  • Mol. W.514.64 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Amino R Isomer trifluoroacetate
Bortezomib Amino R Isomer trifluoroacetate
  • CAT. No.B260017
  • CAS. No.179324-87-9
  • Mol. F.C17H29BF3NO4
  • Mol. W.379.22 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 2 (Mixture of (1S,2R)-Isomer and (1R,2R)-Isomer)
Bortezomib Impurity 2 (Mixture of (1S,2R)-Isomer and (1R,2R)-Isomer)
  • CAT. No.B260018
  • CAS. No.2747958-64-9
  • Mol. F.C19H24N4O3
  • Mol. W.356.43 g/mol
  • Stock Status:Instock
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Bortezomib Impurity 33
Bortezomib Impurity 33
  • CAT. No.B260019
  • CAS. No.948294-96-0
  • Mol. F.C14H23BN2O3
  • Mol. W.278.16 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib N-formyl analog
Bortezomib N-formyl analog
  • CAT. No.B260020
  • CAS. No.NA
  • Mol. F.C15H14N4O3
  • Mol. W.298.30 g/mol
  • Stock Status:Under Synthesis
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Hydroxybortezomib
Hydroxybortezomib
  • CAT. No.B260021
  • CAS. No.NA
  • Mol. F.C19H25BN4O5
  • Mol. W.400.24 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib R-Hydroperoxide
Bortezomib R-Hydroperoxide
  • CAT. No.B260022
  • CAS. No.886979-78-8
  • Mol. F.C19H24N4O4
  • Mol. W.372.42 g/mol
  • Stock Status:Instock
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Bortezomib S-Hydroperoxide
Bortezomib S-Hydroperoxide
  • CAT. No.B260023
  • CAS. No.886979-81-3
  • Mol. F.C19H24N4O4
  • Mol. W.372.42 g/mol
  • Stock Status:Limited Stock
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Bortezomib D-phenylalanyl analog
Bortezomib D-phenylalanyl analog
  • CAT. No.B260024
  • CAS. No.NA
  • Mol. F.C28H34BN5O5
  • Mol. W.531.41 g/mol
  • Stock Status:Custom Synthesis
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(S)-Hydroxy Des(boric Acid) Bortezomib
(S)-Hydroxy Des(boric Acid) Bortezomib
  • CAT. No.B260025
  • CAS. No.289472-81-7
  • Mol. F.C19H24N4O3
  • Mol. W.356.42 g/mol
  • Stock Status:Under Synthesis
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N-(pyrazine-2-yl-carbonyl)-L-phenylalanine
N-(pyrazine-2-yl-carbonyl)-L-phenylalanine
  • CAT. No.B260026
  • CAS. No.1093959-75-1
  • Mol. F.C14H13N3O3
  • Mol. W.271.27 g/mol
  • Stock Status:Instock
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Bortezomib Impurity 7
Bortezomib Impurity 7
  • CAT. No.B260027
  • CAS. No.NA
  • Mol. F.C10H16BN3O3
  • Mol. W.237.07 g/mol
  • Stock Status:Custom Synthesis
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(S)-N-(1-Formamido-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
(S)-N-(1-Formamido-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
  • CAT. No.B260028
  • CAS. No.NA
  • Mol. F.C15H14N4O3
  • Mol. W.298.30 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib USP Imp F
Bortezomib USP Imp F
  • CAT. No.B260029
  • CAS. No.2379402-85-2
  • Mol. F.C19H22N4O4
  • Mol. W.370.40 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 9
Bortezomib Impurity 9
  • CAT. No.B260030
  • CAS. No.1194235-41-0
  • Mol. F.C28H34BN5O5
  • Mol. W.531.41 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 28
Bortezomib Impurity 28
  • CAT. No.B260031
  • CAS. No.18942-49-9
  • Mol. F.C14H19NO4
  • Mol. W.265.30 g/mol
  • Stock Status:Custom Synthesis
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Bortezobib Diastereomers S,S
Bortezobib Diastereomers S,S
  • CAT. No.B260032
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 2 (RR-Isomer)
Bortezomib Impurity 2 (RR-Isomer)
  • CAT. No.B260033
  • CAS. No.NA
  • Mol. F.C19H24N4O3
  • Mol. W.356.43 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Related Compound P
Bortezomib Related Compound P
  • CAT. No.B260034
  • CAS. No.NA
  • Mol. F.C28H34BN5O5
  • Mol. W.531.41 g/mol
  • Stock Status:Limited Stock
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Desisobutyl-n-butyl Bortezomib
Desisobutyl-n-butyl Bortezomib
  • CAT. No.B260035
  • CAS. No.1104011-35-9
  • Mol. F.C19H25BN4O4
  • Mol. W.384.24 g/mol
  • Stock Status:Instock
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Bortezomib Impurity (R,R-Isomer)
Bortezomib Impurity (R,R-Isomer)
  • CAT. No.B260036
  • CAS. No.1132709-15-9
  • Mol. F.C19H25BN4O4
  • Mol. W.384.24 g/mol
  • Stock Status:Custom Synthesis
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3-phenyl-2-(pyrazine-2-carboxamido)propanoic acid
3-phenyl-2-(pyrazine-2-carboxamido)propanoic acid
  • CAT. No.B260037
  • CAS. No.114457-94-2
  • Mol. F.C14H13N3O3
  • Mol. W.271.27 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 6
Bortezomib Impurity 6
  • CAT. No.B260038
  • CAS. No.NA
  • Mol. F.C19H25BN4O5
  • Mol. W.400.24 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Desphenylalanyl Analog
Bortezomib Desphenylalanyl Analog
  • CAT. No.B260039
  • CAS. No.NA
  • Mol. F.C10H16BN3O3
  • Mol. W.237.06 g/mol
  • Stock Status:Custom Synthesis
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(S,R) Bortezomib
(S,R) Bortezomib
  • CAT. No.B260040
  • CAS. No.NA
  • Mol. F.C19H25BN4O4
  • Mol. W.384.24 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 69
Bortezomib Impurity 69
  • CAT. No.B260041
  • CAS. No.NA
  • Mol. F.C29H39BN4O4
  • Mol. W.518.46 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Hydroxyketone Analog
Bortezomib Hydroxyketone Analog
  • CAT. No.B260042
  • CAS. No.2379402-85-2
  • Mol. F.C19H22N4O4
  • Mol. W.370.40 g/mol
  • Stock Status:Custom Synthesis
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N-(2-Pyrazinylcarbonyl)-D-phenylalanine
N-(2-Pyrazinylcarbonyl)-D-phenylalanine
  • CAT. No.B260043
  • CAS. No.1608986-16-8
  • Mol. F.C14H13N3O3
  • Mol. W.271.27 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 74
Bortezomib Impurity 74
  • CAT. No.B260049
  • CAS. No.NA
  • Mol. F.C22H30N4O4
  • Mol. W.414.50 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 73
Bortezomib Impurity 73
  • CAT. No.B260050
  • CAS. No.NA
  • Mol. F.C22H30N4O4
  • Mol. W.414.50 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 4
Bortezomib Impurity 4
  • CAT. No.B260052
  • CAS. No.862894-96-0
  • Mol. F.C19H22N4O3
  • Mol. W.354.41 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 10
Bortezomib Impurity 10
  • CAT. No.B260053
  • CAS. No.390800-88-1
  • Mol. F.C57H69B3N12O9
  • Mol. W.1098.67 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 11
Bortezomib Impurity 11
  • CAT. No.B260054
  • CAS. No.862895-00-9
  • Mol. F.C19H22N4O2
  • Mol. W.338.41 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 41
Bortezomib Impurity 41
  • CAT. No.B260055
  • CAS. No.514820-48-5
  • Mol. F.C21H44BNO2Si2
  • Mol. W.409.56 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 53
Bortezomib Impurity 53
  • CAT. No.B260056
  • CAS. No.NA
  • Mol. F.C14H13N3O3
  • Mol. W.271.27 g/mol
  • Stock Status:Instock
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Bortezomib Impurity 1
Bortezomib Impurity 1
  • CAT. No.B260057
  • CAS. No.1788087-64-8
  • Mol. F.C19H24N4O3
  • Mol. W.356.42 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Intermediate(S,R)
Bortezomib Intermediate(S,R)
  • CAT. No.B260058
  • CAS. No.84110-34-9
  • Mol. F.C14H25BO2
  • Mol. W.236.16 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity C (Mixture of Isomers)
Bortezomib Impurity C (Mixture of Isomers)
  • CAT. No.B260059
  • CAS. No.2379402-85-2
  • Mol. F.C19H25BN4O4
  • Mol. W.384.24 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib R,R and S,S Diastereomer impurities
Bortezomib R,R and S,S Diastereomer impurities
  • CAT. No.B260060
  • CAS. No.NA
  • Mol. F.C38H50B2N8O8
  • Mol. W.768.47 g/mol
  • Stock Status:Limited Stock
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Bortezomib Impurity 3
Bortezomib Impurity 3
  • CAT. No.B260061
  • CAS. No.2748159-75-1
  • Mol. F.C14H14N4O2
  • Mol. W.270.29 g/mol
  • Stock Status:Custom Synthesis
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Isoamylamide Impurity
Isoamylamide Impurity
  • CAT. No.B260062
  • CAS. No.NA
  • Mol. F.C19H24N4O2
  • Mol. W.340.42 g/mol
  • Stock Status:Custom Synthesis
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pyrazine-2-carboxylic acid [1-(1-hydroxy-3-methyl-butylcarbamoyl)-2-phenyl-ethyl]amide
pyrazine-2-carboxylic acid [1-(1-hydroxy-3-methyl-butylcarbamoyl)-2-phenyl-ethyl]amide
  • CAT. No.B260063
  • CAS. No.NA
  • Mol. F.C19H24N4O3
  • Mol. W.356.42 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Trimetric Form
Bortezomib Trimetric Form
  • CAT. No.B260065
  • CAS. No.NA
  • Mol. F.C57H69B3N12O9
  • Mol. W.1098.67 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 31
Bortezomib Impurity 31
  • CAT. No.B260066
  • CAS. No.84110-40-7
  • Mol. F.C4H11BO2
  • Mol. W.101.94 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib D-Mannitol Ester
Bortezomib D-Mannitol Ester
  • CAT. No.B260067
  • CAS. No.444576-08-3
  • Mol. F.C25H35BN4O8
  • Mol. W.530.38 g/mol
  • Stock Status:Custom Synthesis
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N-((S)-1-(((R)-3-methyl-1-((3aS,4R,6R,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
N-((S)-1-(((R)-3-methyl-1-((3aS,4R,6R,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
  • CAT. No.B260068
  • CAS. No.NA
  • Mol. F.C29H39BN4O4
  • Mol. W.518.46 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib impurity U
Bortezomib impurity U
  • CAT. No.B260069
  • CAS. No.NA
  • Mol. F.C19H22N4O3
  • Mol. W.354.40 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 81
Bortezomib Impurity 81
  • CAT. No.B260070
  • CAS. No.NA
  • Mol. F.C25H36BN5O4
  • Mol. W.481.40 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity B
Bortezomib Impurity B
  • CAT. No.B260071
  • CAS. No.NA
  • Mol. F.C28H37BN4O5
  • Mol. W.520.43 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Hydroxy Impurity (1S,2R)-Isomer
Bortezomib Hydroxy Impurity (1S,2R)-Isomer
  • CAT. No.B260072
  • CAS. No.NA
  • Mol. F.C19H24N4O3
  • Mol. W.356.42 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 12
Bortezomib Impurity 12
  • CAT. No.B260073
  • CAS. No.NA
  • Mol. F.C19H24N4O3
  • Mol. W.356.42 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 13
Bortezomib Impurity 13
  • CAT. No.B260074
  • CAS. No.NA
  • Mol. F.C19H24N4O3
  • Mol. W.356.42 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 5
Bortezomib Impurity 5
  • CAT. No.B260075
  • CAS. No.1158974-93-6
  • Mol. F.C5H14BNO2.HCl
  • Mol. W.167.44 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Bortezomib Impurity 1
N-Nitroso Bortezomib Impurity 1
  • CAT. No.B260076
  • CAS. No.NA
  • Mol. F.C19H24BN5O5
  • Mol. W.413.24 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib Impurity 14
Bortezomib Impurity 14
  • CAT. No.B260078
  • CAS. No.85167-14-2
  • Mol. F.C15H26BClO2
  • Mol. W.284.63 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Bortezomib-D8
Bortezomib-D8
  • CAT. No.B260015
  • CAS. No.NA
  • Mol. F.C19H17D8BN4O4
  • Mol. W.392.29 g/mol
  • Stock Status:Custom Synthesis
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Bortezomib-D5
Bortezomib-D5
  • CAT. No.B260064
  • CAS. No.1133706-15-6
  • Mol. F.C19H20D5BN4O4
  • Mol. W.389.27 g/mol
  • Stock Status:Instock
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