Binimetinib Related Compounds & Impurities

Binimetinib is a selective MEK1/2 inhibitor used in combination with encorafenib for BRAF V600-mutant melanoma.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Binimetinib reference standards, pharmacopeial and non-pharmacopeial Binimetinib impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Binimetinib-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Binimetinib
Binimetinib
  • CAT. No.B1270000
  • CAS. No.606143-89-9
  • Mol. F.C17H15BrF2N4O3
  • Mol. W.441.20 g/mol
  • Stock Status:Instock
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N-desmethyl Binimetinib
N-desmethyl Binimetinib
  • CAT. No.B1270003
  • CAS. No.NA
  • Mol. F.C16H13BrF2N4O3
  • Mol. W.427.21 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Acid Impurity
Binimetinib Acid Impurity
  • CAT. No.B1270004
  • CAS. No.1415564-99-6
  • Mol. F.C15H10BrF2N3O2
  • Mol. W.382.16 g/mol
  • Stock Status:Instock
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Binimetinib Des Ethanediol Impurity
Binimetinib Des Ethanediol Impurity
  • CAT. No.B1270005
  • CAS. No.NA
  • Mol. F.C15H11BrF2N4O
  • Mol. W.381.17 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Methyl Ester
Binimetinib Methyl Ester
  • CAT. No.B1270006
  • CAS. No.NA
  • Mol. F.C16H12BrF2N3O2
  • Mol. W.396.19 g/mol
  • Stock Status:Instock
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Binimetinib Impurity 20
Binimetinib Impurity 20
  • CAT. No.B1270007
  • CAS. No.NA
  • Mol. F.C15H11BrF2N4O2
  • Mol. W.397.17 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib N-Oxide
Binimetinib N-Oxide
  • CAT. No.B1270008
  • CAS. No.NA
  • Mol. F.C17H14BrF2N4O4
  • Mol. W.456.22 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Dimer Impurity
Binimetinib Dimer Impurity
  • CAT. No.B1270009
  • CAS. No.NA
  • Mol. F.C23H17Br2F3N4O3
  • Mol. W.614.21 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Ethyleneglycol Ester
Binimetinib Ethyleneglycol Ester
  • CAT. No.B1270010
  • CAS. No.NA
  • Mol. F.C17H15BrF2N4O3
  • Mol. W.441.23 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 2
Binimetinib Impurity 2
  • CAT. No.B1270011
  • CAS. No.391212-29-6
  • Mol. F.C4H9NO2
  • Mol. W.103.12 g/mol
  • Stock Status:Instock
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Binimetinib Impurity 1
Binimetinib Impurity 1
  • CAT. No.B1270012
  • CAS. No.284030-58-6
  • Mol. F.C8H6F2N2O4
  • Mol. W.232.14 g/mol
  • Stock Status:Instock
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Binimetinib Cyclized impurity
Binimetinib Cyclized impurity
  • CAT. No.B1270013
  • CAS. No.NA
  • Mol. F.C21H23BrF2N4O4
  • Mol. W.513.33 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 11
Binimetinib Impurity 11
  • CAT. No.B1270016
  • CAS. No.391212-30-9
  • Mol. F.C12H11NO4
  • Mol. W.233.22 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Des Bromo Impurity
Binimetinib Des Bromo Impurity
  • CAT. No.B1270017
  • CAS. No.NA
  • Mol. F.C17H16F2N4O3
  • Mol. W.362.33 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Des Bromo Acid Impurity
Binimetinib Des Bromo Acid Impurity
  • CAT. No.B1270018
  • CAS. No.2649854-87-3
  • Mol. F.C15H11F2N3O2
  • Mol. W.303.26 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Des Bromo Vinyloxy Impurity
Binimetinib Des Bromo Vinyloxy Impurity
  • CAT. No.B1270019
  • CAS. No.2649854-88-4
  • Mol. F.C19H18F2N4O3
  • Mol. W.388.37 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Ethyl Ether Impurity
Binimetinib Ethyl Ether Impurity
  • CAT. No.B1270020
  • CAS. No.NA
  • Mol. F.C19H19BrF2N4O3
  • Mol. W.469.28 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 10
Binimetinib Impurity 10
  • CAT. No.B1270021
  • CAS. No.2509103-99-3
  • Mol. F.C17H14BrF2N3O2
  • Mol. W.410.20 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 16
Binimetinib Impurity 16
  • CAT. No.B1270022
  • CAS. No.NA
  • Mol. F.C19H17BrF2N4O4
  • Mol. W.483.26 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 17
Binimetinib Impurity 17
  • CAT. No.B1270023
  • CAS. No.NA
  • Mol. F.C19H17BrF2N4O3
  • Mol. W.467.26 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 18
Binimetinib Impurity 18
  • CAT. No.B1270024
  • CAS. No.918321-31-0
  • Mol. F.C7H6FN3O4
  • Mol. W.215.14 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 19
Binimetinib Impurity 19
  • CAT. No.B1270025
  • CAS. No.NA
  • Mol. F.C7H4F2N2O4
  • Mol. W.218.11 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Dibromo Impurity
Binimetinib Dibromo Impurity
  • CAT. No.B1270027
  • CAS. No.NA
  • Mol. F.C17H15Br2FN4O3
  • Mol. W.502.13 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Binimetinib
N-Nitroso Binimetinib
  • CAT. No.B1270028
  • CAS. No.NA
  • Mol. F.C17H14BrF2N5O4
  • Mol. W.470.22 g/mol
  • Stock Status:Instock
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N-Nitroso N-Desmethyl Binimetinib
N-Nitroso N-Desmethyl Binimetinib
  • CAT. No.B1270029
  • CAS. No.NA
  • Mol. F.C16H12BrF2N5O4
  • Mol. W.456.20 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Acid Nitroso Impurity
Binimetinib Acid Nitroso Impurity
  • CAT. No.B1270030
  • CAS. No.NA
  • Mol. F.C15H9BrF2N4O3
  • Mol. W.411.20 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Nitroso Amide Impurity
Binimetinib Nitroso Amide Impurity
  • CAT. No.B1270031
  • CAS. No.NA
  • Mol. F.C21H22BrF2N5O4
  • Mol. W.526.30 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Binimetinib Impurity 1
N-Nitroso Binimetinib Impurity 1
  • CAT. No.B1270032
  • CAS. No.NA
  • Mol. F.C16H13BrF2N6O4
  • Mol. W.471.21 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 3
Binimetinib Impurity 3
  • CAT. No.B1270033
  • CAS. No.NA
  • Mol. F.C19H16BrF2N5O4
  • Mol. W.496.26 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 4
Binimetinib Impurity 4
  • CAT. No.B1270034
  • CAS. No.1415559-89-5
  • Mol. F.C16H13F2N3O2
  • Mol. W.317.29 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Des Ethanediol Impurity
N-Nitroso Des Ethanediol Impurity
  • CAT. No.B1270035
  • CAS. No.NA
  • Mol. F.C15H10BrF2N5O2
  • Mol. W.410.17 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Amide Impurity
Binimetinib Amide Impurity
  • CAT. No.B1270036
  • CAS. No.1604812-70-5
  • Mol. F.C21H23BrF2N4O3
  • Mol. W.497.33 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 5
Binimetinib Impurity 5
  • CAT. No.B1270037
  • CAS. No.2851526-49-1
  • Mol. F.C17H14BrF2N3O3
  • Mol. W.426.20 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 6
Binimetinib Impurity 6
  • CAT. No.B1270038
  • CAS. No.606143-94-6
  • Mol. F.C14H11F2N3O4
  • Mol. W.323.25 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

N-Desmethyl Binimetinib Hydrochloride
N-Desmethyl Binimetinib Hydrochloride
  • CAT. No.B1270014
  • CAS. No.NA
  • Mol. F.C16H14BrClF2N4O3
  • Mol. W.463.66 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Glucuronide
Binimetinib Glucuronide
  • CAT. No.B1270015
  • CAS. No.NA
  • Mol. F.C23H23BrF2N4O9
  • Mol. W.617.36 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Binimetinib 13C2-D4
Binimetinib 13C2-D4
  • CAT. No.B1270026
  • CAS. No.NA
  • Mol. F.C1513C2H11D4BrF2N4O3
  • Mol. W.447.24 g/mol
  • Stock Status:Instock
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