Solvents
where one or more hydrogen atoms are substituted with Deuterium atoms are
termed as Deuterated Solvents. Deuterated solvents used for NMR
spectroscopy.
Examples for
Deuterated Solvents;
water
(D2O)chloroform (CDCl3), dichloromethane (CD2Cl2), dimethyl sulfoxide
(DMSO-d6), acetonitrile (CD3CN), methanol (CD3OD), acetone (acetone-d6),
benzene (C6D6), toluene (toluene-d8), tetrahydrofuran (THF-d8), and
trifluoroacetic acid (TFA-d).
There are three
main reasons to use Deuterated Solvents in Nuclear Magnetic Resonance
Spectroscopy:
A-To avoid
swamping by the solvent signal.
An ordinary proton-containing solvent
gives a huge solvent absorption that would dominate the 1H-NMR spectrum and
interfere with the peaks of protons of interest. Most 1H- NMR spectra are
therefore recorded in a deuterated solvent, because deuterium atoms absorb at a
completely different frequency.
B - To
stabilize the magnetic field strength.
The field strength of
superconducting magnets tends to drift slowly. Modern NMR spectrometers measure
the deuterium absorption of the solvent and adjust the field strength to keep
the resonance frequency (field strength) constant.
C-To accurately
define 0 ppm.
The difference between the deuterium
frequency and 0 ppm (TMS) is well known.
To
satisfy the most rigorous demands of NMR-based research and analyses, high
quality, high purity, and highly enriched deuterated solvents are required.
Deuterated solvent must be purified and analyzed for the presence of water
content.
Simson
pharma Pvt Ltd is committed to providing a range of NMR solvents for routine
use with good chemical purity and with the highest isotopic enrichment.
These
are some example of deuterated solvent we do provide,
1.
Chloroform-d(CDCl3)
Catalog
ID: OT215001
CAS Number: 865-49-6
For more details: https://www.simsonpharma.com/product/chloroform-d
(2).
Dimethyl Sulfoxide – D6 (DMSO-D6
Catalog
ID: OT1062001
CAS
Number: 2206-27-1
For
more details: https://www.simsonpharma.com/product/dimethyl-sulfoxide-d6