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vACEBROPHYLLINE belongs to the class of drugs called bronchodilators primarily used to prevent and treat symptoms of asthma and chronic obstructive pulmonary disease (COPD). 

vACEBROPHYLLINE contains Acebrophylline that works by relaxing muscles and widening the airways of the lungs.

 vACEBROPHYLLINE acts as mucolytic (cough/sputum thinner) agent and helps in thinning and loosening phlegm (mucus) in lungs, windpipe and nose. Thereby, it helps to cough out easily and makes breathing easier by opening airways.

 vACEBROPHYLLINE is a compound found to act as a bronchodilating, mucoregulating and anti-inflammatory drug due to its components theophylline-7-acetate and ambroxol.Theophylline-7-acetate, with other xanthinic derivatives, has a bronchodilator effect due to inhibition of the intracellular phosphodiesterases, followed by an increase of adenosine monophosphate cyclic levels, which promote the relaxation of bronchial muscles.


ACEBROPHYLLINE inhibits phospholipase A2 and phosphatidylcholine leading to lesser production of the powerful pro-inflammatory substances like leukotrienes and tumor necrosis factor. By inhibiting the synthesis and release of these inflammatory mediators, acebrophylline reduces inflammation, a key factor in airway obstruction, especially in chronic forms.

Theophylline is an age old bronchodilator and anti-inflammatory agent while ACEBROPHYLLINE is a newer one. Both are used as add on therapy in management of stable COPD patients on LAMA (long acting muscarinic antagonists like Tiotropium) in present day respiratory practice

Some of the impurities of Acebrophylline are tabulated below. These impurities are identified, isolated, purified and characterized after enormous research


Product Name

Chemical Name

Cas No.


 - API

1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purine-7-acetic acid:trans-4-[[(2-Amino-3,5-dibromophenyl)methyl]amino]cyclohexanol



2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-9(6H)-yl)acetic acid






cis-4-[(2-amino-3,5-dibromobenzyl) amino]cyclohexanol


Acebrophylline Impurity F Hyrochloride

Trans 4-((2-amino-5-bromobenzyl) amino) cyclohexanol hydrochloride

101900-43-0 (Free Base)

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